USP14 抗体 (N-Term)
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- 抗原 See all USP14 抗体
- USP14 (Ubiquitin Specific Peptidase 14 (USP14))
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抗原表位
- AA 1-30, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This USP14 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- B, M
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USP14.
- 克隆位点
- RB4334
- 亚型
- Ig Fraction
- Top Product
- Discover our top product USP14 Primary Antibody
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- 应用备注
- WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).
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Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).
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- 抗原
- USP14 (Ubiquitin Specific Peptidase 14 (USP14))
- 别名
- USP14 (USP14 产品)
- 别名
- TGT antibody, DDBDRAFT_0202821 antibody, DDBDRAFT_0237695 antibody, DDB_0202821 antibody, DDB_0237695 antibody, 2610005K12Rik antibody, 2610037B11Rik antibody, AW107924 antibody, C78769 antibody, ax antibody, zgc:55949 antibody, wu:fk63d09 antibody, MGC81945 antibody, tgt antibody, MGC69343 antibody, USP14 antibody, ubiquitin specific peptidase 14 antibody, peptidase C19 family protein antibody, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) antibody, ubiquitin specific protease 14 antibody, ubiquitin specific peptidase 14 S homeolog antibody, universal stress protein antibody, Ubiquitin carboxyl-terminal hydrolase 14 antibody, USP14 antibody, usp14 antibody, Usp14 antibody, Bm1_28765 antibody, usp14.S antibody, RR_RS06480 antibody, usp-14 antibody
- 背景
- Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
- 分子量
- 56069
- 基因ID
- 9097
- NCBI登录号
- NP_001032411, NP_005142
- UniProt
- P54578
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