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USP2 抗体 (N-Term)

Name: USP2 抗体 (N-Term)
SKU: ABIN388877
Availability: OutOfStock

USP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4202 unconjugated

Western blot analysis of USP2 Antibody (N-term) (ABIN388877 and ABIN2839170) in HL60 cell line lysates (35 μg/lane). (USP2 抗体 (N-Term))

IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. (USP2 抗体 (N-Term))

IHC (p)

Western blot analysis of USP2 (arrow) using rabbit polyclonal USP2 Antibody (T22) (ABIN388877 and ABIN2839170). (USP2 抗体 (N-Term))

Western blot analysis of lysate from R. (USP2 抗体 (N-Term))

4 images

(4 references)

产品编号 ABIN388877

发货至: 中国

Datasheet as PDF

抗原 See all USP2 抗体

USP2 (Ubiquitin Specific Peptidase 2 (USP2))
抗原表位
15

8

8

7

6

5

4

4

3

2

2

1

1

1

1

1

1
AA 71-101, N-Term
适用
65

8

7

6

5

5

5

3

3

1

1

1

1

1

1

1
人, 大鼠
宿主
61

4
兔
Compatible Secondaries
克隆类型
63

2
多克隆
标记
32

7

6

6

4

4

1

1

1

1

1

1
This USP2 antibody is un-conjugated
应用范围
47

37

24

4

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of human USP2.

克隆位点

RB4202

亚型

Ig Fraction

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anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 508-538), (C-Term) antibody
USP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4417 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 200-430), (C-Term) antibody
USP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) antibody
USP2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibody
USP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 9-265) antibody
USP2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-258) antibody
USP2 适用: 人, Green Monkey WB 宿主: 小鼠 Monoclonal 1738CT331-50-87 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 245-275) antibody
USP2 适用: 人宿主: 兔 Polyclonal RB4416 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibody
USP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-120) antibody
USP2 适用: 人, 大鼠, 犬, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 371-420) antibody
USP2 适用: 人, 犬, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Kitamura, Ishino, Shimamoto, Okabe, Miyamoto, Takahashi, Miyoshi: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." in: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).

Kitamura, Kimura, Shimamoto, Okabe, Ito, Miyamoto, Naoe, Kikuguchi, Meek, Toda, Okamoto, Kanehira, Hase, Watarai, Ishizuka, El-Osta, Ohara, Miyoshi: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).

Stevenson, Sparks, Allende-Vega, Xirodimas, Lane, Saville: "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2." in: The EMBO journal, Vol. 26, Issue 4, pp. 976-86, (2007) (PubMed).

Priolo, Tang, Brahamandan, Benassi, Sicinska, Ogino, Farsetti, Porrello, Finn, Zimmermann, Febbo, Loda: "The isopeptidase USP2a protects human prostate cancer from apoptosis." in: Cancer research, Vol. 66, Issue 17, pp. 8625-32, (2006) (PubMed).
抗原

USP2 (Ubiquitin Specific Peptidase 2 (USP2))

别名

USP2 (USP2 产品)

别名

UBP41 antibody, USP9 antibody, B930035K21Rik antibody, Ubp41 antibody, UBP-t antibody, UBP46 antibody, ubp52 antibody, ubp66 antibody, zgc:92134 antibody, ubiquitin specific peptidase 2 antibody, ubiquitin specific peptidase 2a antibody, USP2 antibody, Usp2 antibody, usp2a antibody

背景

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

分子量

68072

基因ID

9099

NCBI登录号

NP_001230688, NP_004196, NP_741994

UniProt

O75604