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ATG16L1 抗体 (AA 161-190)

Name: ATG16L1 抗体 (AA 161-190)
SKU: ABIN388542
Availability: OutOfStock

ATG16L1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB07490 unconjugated

G16L Antibody 1817b western blot analysis in NCI- cell line lysates (35 μg/lane). (ATG16L1 抗体 (AA 161-190))

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with Autophagy G16L antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ATG16L1 抗体 (AA 161-190))

IHC (p)

Anti-ATG16L Antibody at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 μg per lane. (ATG16L1 抗体 (AA 161-190))

Western blot of G16L (L92) Pab 1817b in mouse brain tissue lysate. (ATG16L1 抗体 (AA 161-190))

Immunofluorescent analysis of cells, using ATG16L Antibody (ABIN388542 and ABIN2849682). (ATG16L1 抗体 (AA 161-190))

5 images

(8 references)

产品编号 ABIN388542

发货至: 中国

Datasheet as PDF

抗原 See all ATG16L1 抗体

ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))
抗原表位
16

6

5

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 161-190
适用
77

49

33

11

6

6

6

6

6

4

3

2

1

1
人, 小鼠
宿主
80

11

1
兔
Compatible Secondaries
克隆类型
75

17
多克隆
标记
48

5

5

3

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1
This ATG16L1 antibody is un-conjugated
应用范围
66

29

26

15

14

12

10

9

8

4

3

3

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This ATG16L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from human ATG16L.

克隆位点

RB07490

亚型

Ig Fraction

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anti-ATG16 Autophagy Related 16-Like 1 (ATG16L1) (AA 90-300) antibody
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anti-ATG16 Autophagy Related 16-Like 1 (ATG16L1) (AA 11-257) antibody
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anti-ATG16 Autophagy Related 16-Like 1 (ATG16L1) (pSer287) antibody
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anti-ATG16 Autophagy Related 16-Like 1 (ATG16L1) (AA 90-300) antibody
ATG16L1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Li, Guo, Yang, Li, Yang, Liu, Liu, Jiang: "1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice." in: Obesity (Silver Spring, Md.), Vol. 25, Issue 3, pp. 561-571, (2017) (PubMed).

Wang, Chen, Yeo, Karsli-Uzunbas, White, Mizushima, Virgin, Guan: "Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide." in: The Journal of cell biology, Vol. 212, Issue 5, pp. 545-60, (2016) (PubMed).

Zhang, Li, Zhang, Zhang, Teves, Liu, Strauss, Pazour, Foster, Hess, Zhang: "Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice." in: Molecular biology of the cell, (2016) (PubMed).

Wu, Zhang, Lu, Xia, Zhou, Petrof, Claud, Chen, Chang, Carmeliet, Sun: "Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis." in: Gut, Vol. 64, Issue 7, pp. 1082-94, (2015) (PubMed).

Wang, Mendonsa, Symington, Zhang, Cadwell, Virgin, Mysorekar: "Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 27, pp. 11008-13, (2012) (PubMed).

Nascimento-Ferreira, Santos-Ferreira, Sousa-Ferreira, Auregan, Onofre, Alves, Dufour, Colomer Gould, Koeppen, Déglon, Pereira de Almeida: "Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease." in: Brain : a journal of neurology, Vol. 134, Issue Pt 5, pp. 1400-15, (2011) (PubMed).

Travassos, Carneiro, Ramjeet, Hussey, Kim, Magalhães, Yuan, Soares, Chea, Le Bourhis, Boneca, Allaoui, Jones, Nuñez, Girardin, Philpott: "Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry." in: Nature immunology, Vol. 11, Issue 1, pp. 55-62, (2009) (PubMed).

Nomura, Uzawa, Yamano, Fushimi, Ishigami, Kouzu, Koike, Siiba, Bukawa, Yokoe, Kubosawa, Tanzawa: "Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis." in: Human pathology, Vol. 40, Issue 1, pp. 83-91, (2008) (PubMed).
抗原

ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

别名

ATG16L (ATG16L1 产品)

别名

APG16L antibody, ATG16A antibody, ATG16L antibody, IBD10 antibody, WDR30 antibody, 1500009K01Rik antibody, Apg16l antibody, Atg16l antibody, Wdr30 antibody, atg16 antibody, atg16l antibody, fb57e05 antibody, wu:fb57e05 antibody, zgc:110147 antibody, autophagy related 16 like 1 antibody, autophagy related 16-like 1 (S. cerevisiae) antibody, autophagy related 16-like 1 antibody, autophagy related 16 like 1 S homeolog antibody, ATG16 autophagy related 16-like 1 (S. cerevisiae) antibody, ATG16L1 antibody, Atg16l1 antibody, atg16l1 antibody, atg16l1.S antibody

背景

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.

分子量

68265

基因ID

55054

NCBI登录号

NP_001177195, NP_001177196, NP_060444, NP_110430, NP_942593

UniProt

Q676U5

途径

Autophagy