HRH3 抗体 (C-Term)
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- 抗原 See all HRH3 抗体
- HRH3 (Histamine Receptor H3 (HRH3))
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抗原表位
- AA 414-442, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HRH3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This HRH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-442 amino acids from the C-terminal region of human HRH3.
- 克隆位点
- RB01071
- 亚型
- Ig Fraction
- Top Product
- Discover our top product HRH3 Primary Antibody
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anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibody
HRH3 适用: 人, 猴 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 236-332) antibodyHRH3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 250-350) antibodyHRH3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) antibodyHRH3 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (C-Term) antibodyHRH3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 121-220) antibodyHRH3 适用: 人, 大鼠 WB, IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibodyHRH3 适用: 人, 大鼠, 小鼠, 马, Cow, 豚鼠, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibodyHRH3 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 257-359) antibodyHRH3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Histamine Receptor H3 (HRH3) (C-Term) antibodyHRH3 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- HRH3 (Histamine Receptor H3 (HRH3))
- 别名
- HRH3 (HRH3 产品)
- 别名
- GPCR97 antibody, HH3R antibody, AW049250 antibody, H3R antibody, histamine receptor H3 antibody, HRH3 antibody, Hrh3 antibody
- 背景
- The histamine receptor H3 (HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. HRH3 has significant sequence homology to members of the biogenic amine subfamily of GPCRs. Most notable is an aspartic acid residue in the predicted third transmembrane domain, which is a hallmark of the biogenic amine receptor subfamily, this residue is the putative binding site for the primary amine. HRH3 shares 22 % and 21.4 % amino acid sequence homology with the H1 and H2 receptors, respectively. Expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Northern blot analysis of human tissues showed HRH3 expression only in the brain, with highest expression in the thalamus and caudate nucleus. Whereas Northern blot analysis did not detect HRH3 expression in any peripheral tissue examined, RT-PCR showed expression in human small intestine, testis, and prostate. In situ hybridization of rat brain sections showed that Hrh3 is abundantly expressed in brain. Hrh3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle. In addition, Hrh3 expression was found in the locus ceruleus and in the histaminergic cell bodies in the tuberomammillary nuclei.
- 分子量
- 48671
- 基因ID
- 11255
- NCBI登录号
- NP_009163
- UniProt
- Q9Y5N1
- 途径
- cAMP Metabolic Process, Feeding Behaviour
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