SUMO4 抗体 (Mutant, Val55)
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- 抗原 See all SUMO4 抗体
- SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
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抗原表位
- Mutant, Val55
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SUMO4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
- 克隆位点
- RB7264
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SUMO4 Primary Antibody
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anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibody
SUMO4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D3 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63) antibodySUMO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7262 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63), (Wild Type) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (Met55Val-Mutant) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (Met55Val-Mutant) antibodySUMO4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
- 别名
- SUMO4 (SUMO4 产品)
- 别名
- IDDM5 antibody, SMT3H4 antibody, SUMO-4 antibody, dJ281H8.4 antibody, small ubiquitin-like modifier 4 antibody, small ubiquitin-related modifier 4 antibody, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antibody, SUMO4 antibody, sumo4 antibody
- 背景
- SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
- 分子量
- 10685
- 基因ID
- 387082
- NCBI登录号
- NP_001002255
- UniProt
- Q6EEV6
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