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SUV39H1 抗体 (N-Term)

SUV39H1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2153 unconjugated
产品编号 ABIN387991
发货至: 中国
  • 抗原 See all SUV39H1 抗体
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    抗原表位
    • 17
    • 15
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 67
    • 17
    • 7
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 59
    • 8
    克隆类型
    • 59
    • 8
    多克隆
    标记
    • 23
    • 7
    • 6
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SUV39H1 antibody is un-conjugated
    应用范围
    • 39
    • 35
    • 13
    • 13
    • 12
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
    克隆位点
    RB2153
    亚型
    Ig Fraction
    Top Product
    Discover our top product SUV39H1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Chen, Yeh, Yang, Chang, Lee, Hung: "High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 513, (2013) (PubMed).

    Benlhabib, Mendelson: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." in: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, (2011) (PubMed).

  • 抗原
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    别名
    SUV39H1 (SUV39H1 产品)
    别名
    H3-K9-HMTase 1 antibody, KMT1A antibody, MG44 antibody, SUV39H antibody, AI852103 antibody, AL022883 antibody, DXHXS7466e antibody, mIS6 antibody, RGD1565028 antibody, kmt1a antibody, suv39h antibody, fe02c04 antibody, suv39h1 antibody, wu:fe02c04 antibody, zgc:101027 antibody, fe47h06 antibody, wu:fb18a10 antibody, wu:fe47h06 antibody, zgc:136593 antibody, suppressor of variegation 3-9 homolog 1 antibody, suppressor of variegation 3-9 homolog 1 (Drosophila) antibody, suppressor of variegation 3-9 homolog 1 L homeolog antibody, suppressor of variegation 3-9 homolog 1a antibody, suppressor of variegation 3-9 homolog 1b antibody, SUV39H1 antibody, Suv39h1 antibody, suv39h1.L antibody, suv39h1a antibody, suv39h1b antibody
    背景
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
    分子量
    47907
    基因ID
    6839
    NCBI登录号
    NP_001269095, NP_003164
    UniProt
    O43463
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