Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
预测反应
M, Rat
纯化方法
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
免疫原
This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1).
KAT1 antibody, HAC07 antibody, HAC7 antibody, HAG02 antibody, MIK19.19 antibody, MIK19_19 antibody, histone acetyltransferase of the GNAT family 2 antibody, hac106 antibody, hat1 antibody, zgc:92639 antibody, histone acetyltransferase 1 antibody, histone acetyltransferase of the GNAT family 2 antibody, histone acetyltransferase catalytic subunit antibody, histone acetyltransferase Hat1 antibody, histone acetyltransferase 1 L homeolog antibody, HAT1 antibody, Hat1 antibody, HAG2 antibody, hat1 antibody, hat1.L antibody
背景
Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.