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JMJD4 抗体 (C-Term)

JMJD4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB10802 unconjugated
产品编号 ABIN387875
发货至: 中国
  • 抗原 See all JMJD4 products
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    抗原表位
    • 8
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    AA 423-455, C-Term
    适用
    • 26
    • 11
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 26
    克隆类型
    • 26
    多克隆
    标记
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This JMJD4 antibody is un-conjugated
    应用范围
    • 26
    • 15
    • 8
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-455 amino acids from the C-terminal region of human JMJD4.
    克隆位点
    RB10802
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    别名
    JMJD4 (JMJD4 产品)
    别名
    JMJD4 antibody, 6430559I23 antibody, RGD1307186 antibody, jumonji domain containing 4 antibody, jumonji domain containing 4 L homeolog antibody, JMJD4 antibody, jmjd4.L antibody, Jmjd4 antibody
    背景
    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
    分子量
    52493
    基因ID
    65094
    NCBI登录号
    NP_001154937, NP_075383
    UniProt
    Q9H9V9
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