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Kdm6b 抗体 (N-Term)

Name: Kdm6b 抗体 (N-Term)
SKU: ABIN387862
Availability: OutOfStock

Kdm6b 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB10077 unconjugated

Western blot analysis of anti-JMJD3 (N-term) Pab ((ABIN387862 and ABIN2844039)) in Hela cell line lysates. (Kdm6b 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human brain tissue reacted with JMJD3 (N-term) (ABIN387862 and ABIN2844039) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Kdm6b 抗体 (N-Term))

IHC (p)

Confocal immunofluorescent analysis of JMJD3 Antibody (N-term) (ABIN387862 and ABIN2844039) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Kdm6b 抗体 (N-Term))

3 images

(15 references)

产品编号 ABIN387862

发货至: 中国

Datasheet as PDF

抗原 See all Kdm6b 抗体

Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
抗原表位
8

6

6

6

3

3

2

2

1

1

1

1

1

1

1

1

1

1
AA 1-30, N-Term
适用
43

25

10

6

4

4

4

3

2

2

1

1
人
宿主
46

1

1
兔
Compatible Secondaries
克隆类型
47

1
多克隆
标记
31

4

2

2

2

1

1

1

1

1

1

1
This Kdm6b antibody is un-conjugated
应用范围
36

21

10

6

6

4

3
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

M

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD3.

克隆位点

RB10077

亚型

Ig Fraction

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anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1-30) antibody
Kdm6b 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1606-1641), (C-Term) antibody
Kdm6b 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB10081-RB10082 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1530-1682) antibody
Kdm6b 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1023-1057) antibody
Kdm6b 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50943 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 879-912) antibody
Kdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51280 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibody
Kdm6b 适用: 人, 大鼠, 犬, 兔, Cow, 马, 猴, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1613-1662) antibody
Kdm6b 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1161-1350) antibody
Kdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (Middle Region) antibody
Kdm6b 适用: 人, 小鼠, 大鼠, 犬, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Angrisano, Pero, Brancaccio, Coretti, Florio, Pezone, Calabrò, Falco, Keller, Lembo, Avvedimento, Chiariotti: "Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells." in: PLoS ONE, Vol. 11, Issue 6, pp. e0156671, (2017) (PubMed).

Petruk, Mariani, De Dominici, Porazzi, Minieri, Cai, Iacovitti, Flomenberg, Calabretta, Mazo: "Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification." in: Cell reports, Vol. 19, Issue 2, pp. 295-306, (2017) (PubMed).

Liao, Kuo, Lu, Wang, Wu: "Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer." in: International journal of oncology, Vol. 46, Issue 4, pp. 1788-800, (2015) (PubMed).

Hashizume, Andor, Ihara, Lerner, Gan, Chen, Fang, Huang, Tom, Ngo, Solomon, Mueller, Paris, Zhang, Petritsch, Gupta, Waldman, James: "Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma." in: Nature medicine, (2014) (PubMed).

Lee, Na, Lee, Na, Cho, Wu, Yune, Kim, Ju: "Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury." in: Journal of neurochemistry, Vol. 122, Issue 2, pp. 272-82, (2013) (PubMed).

Ramadoss, Chen, Wang: "Histone demethylase KDM6B promotes epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 287, Issue 53, pp. 44508-17, (2012) (PubMed).

Balasubramanian, Chew, Eckert: "Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells." in: Molecular pharmacology, Vol. 80, Issue 5, pp. 870-8, (2011) (PubMed).

Hyland, McDade, McCloskey, Dickson, Arthur, McCance, Patel: "Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes." in: Journal of virology, Vol. 85, Issue 21, pp. 10999-1006, (2011) (PubMed).

Kim, Yoon, Chuong, Oyolu, Wills, Gupta, Baker: "Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs." in: Developmental biology, Vol. 357, Issue 2, pp. 492-504, (2011) (PubMed).

Lu, Lu, Liao, Yu, Chung, Kao, Wu: "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 8719-32, (2010) (PubMed).

Dai, Lu, Zhang, Shen: "Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells." in: Journal of cellular biochemistry, Vol. 110, Issue 6, pp. 1457-63, (2010) (PubMed).

Toth, Maglinte, Lee, Lee, Wong, Brulois, Lee, Buckley, Laird, Marquez, Jung: "Epigenetic analysis of KSHV latent and lytic genomes." in: PLoS pathogens, Vol. 6, Issue 7, pp. e1001013, (2010) (PubMed).

Peláez, Kalogeropoulou, Ferraro, Voulgari, Pankotai, Boros, Pintzas: "Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 42, Issue 6, pp. 911-20, (2010) (PubMed).

Long, Huang, Yin, Zhao, Zhao, Lu: "Abnormal expression pattern of histone demethylases in CD4(+) T cells of MRL/lpr lupus-like mice." in: Lupus, Vol. 18, Issue 14, pp. 1327-8, (2009) (PubMed).

Ishii, Wen, Corsa, Liu, Coelho, Allen, Carson, Cavassani, Li, Lukacs, Hogaboam, Dou, Kunkel: "Epigenetic regulation of the alternatively activated macrophage phenotype." in: Blood, Vol. 114, Issue 15, pp. 3244-54, (2009) (PubMed).
抗原

Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

别名

JMJD3 (Kdm6b 产品)

别名

jmjd3 antibody, kdm6b antibody, si:ch211-237l4.7 antibody, 1700064E03Rik antibody, BC038313 antibody, Jmjd3 antibody, mKIAA0346 antibody, JMJD3 antibody, lysine (K)-specific demethylase 6B antibody, lysine demethylase 6B antibody, lysine (K)-specific demethylase 6B, b antibody, KDM1 lysine (K)-specific demethylase 6B antibody, kdm6b antibody, KDM6B antibody, kdm6bb antibody, Kdm6b antibody

背景

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

分子量

176632

基因ID

23135

NCBI登录号

NP_001073893

UniProt

O15054

途径

Warburg Effect