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AIRE 抗体 (Internal Region, Isoform 1)

Name: AIRE 抗体 (Internal Region, Isoform 1)
SKU: ABIN374692
Availability: OutOfStock

AIRE 适用: 人, 大鼠, 犬 WB, IHC (p), EIA 宿主: 山羊 Polyclonal unconjugated

Image no. 1 for anti-Autoimmune Regulator (AIRE) (Internal Region), (Isoform 1) antibody (ABIN374692) (AIRE 抗体 (Internal Region, Isoform 1))

1 image

(6 references)

产品编号 ABIN374692

发货至: 中国

Datasheet as PDF

抗原 See all AIRE 抗体

AIRE (Autoimmune Regulator (AIRE))
抗原表位
10

9

5

5

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region, Isoform 1
适用
53

23

7

5

3

3

3

3

2
人, 大鼠, 犬
宿主
48

7

1
山羊
Compatible Secondaries
克隆类型
55
多克隆
标记
40

3

3

2

1

1

1

1

1

1

1

1
This AIRE antibody is un-conjugated
应用范围
41

26

19

8

7

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

序列

C-KDVDLSQPRK GRKP

特异性

This antibody is expected to recognise isoform 1 (NP_000374.1) only.

交叉反应（详细）

Species reactivity (expected):Rat, Canine and Cow.
Species reactivity (tested):Human.

纯化方法

Ammonium sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

免疫原

Peptide with sequence from the internal region of the protein sequence according to NP_000374.1.

Top Product

Discover our top product AIRE Primary Antibody
anti-Autoimmune Regulator (AIRE) (AA 30-130) antibody
AIRE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (C-Term) antibody
Verified AIRE 适用: 人 WB, ELISA, IF, IHC, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (N-Term) antibody
AIRE 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (Internal Region) antibody
AIRE 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (Internal Region) antibody
Verified AIRE 适用: 人, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 39-108) antibody
AIRE 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (pSer156) antibody
AIRE 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 467-516) antibody
AIRE 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 218-267) antibody
AIRE 适用: 人, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) antibody
AIRE 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated

应用备注

Peptide ELISA: 1/32000. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry: 2.5 μg/mL. In paraffin embedded Human Thymus shows nuclear staining in select thymocytes.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
Nakasatomi, Maeshima, Mishima, Ikeuchi, Sakairi, Kaneko, Hiromura, Nojima: "Novel approach for the detection of tubular cell migration into the interstitium during renal fibrosis in rats." in: Fibrogenesis & tissue repair, Vol. 8, pp. 12, (2015) (PubMed).

Ströbel, Hartmann, Rosenwald, Kalla, Ott, Friedel, Schalke, Kasahara, Tomaru, Marx: "Corticomedullary differentiation and maturational arrest in thymomas." in: Histopathology, Vol. 64, Issue 4, pp. 557-66, (2014) (PubMed).

Jüngling, Liu, Lesting, Coulon, Sosulina, Reinscheid, Pape: "Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor." in: The Journal of physiology, Vol. 590, Issue Pt 16, pp. 3701-17, (2012) (PubMed).

Wei, Akerman, Newey, Pan, Clinch, Jacob, Shen, Wilkins, Ellory: "The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism." in: The Journal of physiology, Vol. 589, Issue Pt 22, pp. 5349-59, (2011) (PubMed).

Yuan, Zhu, Zhou, Chen, Zhu, Ma, He, Tian, Shi: "Role of mast cell activation in inducing microglial cells to release neurotrophin." in: Journal of neuroscience research, Vol. 88, Issue 6, pp. 1348-54, (2010) (PubMed).

Zelano, Berg, Thams, Hailer, Cullheim: "SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury." in: The Journal of comparative neurology, Vol. 517, Issue 5, pp. 670-82, (2009) (PubMed).
抗原

AIRE (Autoimmune Regulator (AIRE))

别名

AIRE / APECED (AIRE 产品)

背景

AIRE is a transcriptional regulator that is thought to be important in controlling tissue-specific expression of genes in the thymus. The precise function of the protein is not well defined. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. The longer AIRE1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE3 includes the same exon 1-8-9 sequences as found in AIRE2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).Synonyms: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator

基因ID

326, 9606

UniProt

O43918

途径

Chromatin Binding