FOXL2
适用: 小鼠
IHC, IF
宿主: 兔
Polyclonal
unconjugated
应用备注
Peptide ELISA: Limit dilution 1: 16000. Western blot: 1-2 μg/mL. Approx 45-50 kDa band observed in Human Ovary extracts(predicted MW of 40 kDa according to NP_075555). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
There are 2 forms of the blepharophimosis/ptosis/epicanthus inversus syndrome. In one form, called type I, eyelid abnormalities are associated with ovarian failure. In the second type, called type II, only the eyelid defects are found. Both types map to 3q23. Crisponi et al. (2001) refined the physical mapping of the BPES critical region and positionally cloned a novel, putative winged helix/forkhead transcription factor gene, FOXL2, in which they found mutations to produce truncated proteins in type I families and larger proteins in type II. Consistent with an involvement in those tissues, FOXL2 was selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles, in adult humans, it appeared predominantly in the ovary.Synonyms: Forkhead box protein L2