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Parkin 抗体 (pSer378)
PARK2
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
Parkin抗体详情
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抗原
See all Parkin (PARK2) 抗体
Parkin (PARK2)
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
抗原表位
All epitopes for Parkin 抗体
pSer378
适用
All reactivities for Parkin 抗体
人
宿主
All hosts for Parkin 抗体
兔
克隆类型
All clonalities for Parkin 抗体
多克隆
标记
All conjugates for Parkin 抗体
This Parkin antibody is un-conjugated
应用范围
All applications for Parkin 抗体
Western Blotting (WB)
特异性
This antibody recognizes the ~52k Parkin protein phosphorylated at Ser378. Immunolabeling of the parkin band is absent in parkin S378 mutants.
交叉反应 (详细)
Species reactivity (tested):Human.
纯化方法
Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
免疫原
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser378 of human Parkin.
亚型
IgG
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Alternatives
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使用细节
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应用备注
Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
贮存及处理
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状态
Liquid
缓冲液
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
注意事项
Avoid repeated freezing and thawing.
储存条件
-20 °C
储存方法
Store the antibody undiluted (in aliquots) at-20 °C.
Parkin目标详情
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抗原
Parkin (PARK2)
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
别名
PARK2 / Parkin (PARK2 产品 )
别名
CG10523 antibody, Dmel\\CG10523 antibody, Dpark antibody, SD01679 antibody, dpk antibody, AR-JP antibody, LPRS2 antibody, PDJ antibody, PRKN antibody, Park antibody, Prkn antibody, si:ch211-123f21.1 antibody, zgc:112390 antibody, pdr-1 antibody, PARK2 antibody, parkin antibody, parkin RBR E3 ubiquitin protein ligase antibody, Parkinson disease (autosomal recessive, juvenile) 2, parkin antibody, park antibody, PRKN antibody, Prkn antibody, prkn antibody, CpipJ_CPIJ014867 antibody, Park2 antibody
背景
Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson's disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner et al.,1992). Recent evidence suggests that phosphorylation of parkin at Ser378 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).Synonyms: AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PDJ, PRKN, Parkinson disease 2, Parkinson juvenile disease protein 2
基因ID
5071
NCBI登录号
NP_004553
UniProt
O60260
途径
Autophagy , Ubiquitin Proteasome Pathway
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