GRIN2C 抗体 (N-Term)
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- 抗原 See all GRIN2C 抗体
- GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRIN2C antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 特异性
- This antibody recognizes the ~140k NR2C subunit of the NMDA Receptor. Also labels the ~180k NR2A and the ~180k NR2B subunits of the NMDA Receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.
- 交叉反应 （详细）
- Species reactivity (tested):Human, Mouse and Rat.
- 纯化方法
- Affinity Chromatography.
- 免疫原
- Fusion protein from the N-terminus of the NR2C-subunit of Rat NMDA receptor.
- 亚型
- IgG
- Top Product
- Discover our top product GRIN2C Primary Antibody
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (N-Term) antibody
GRIN2C 适用: 大鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 908-1007) antibodyGRIN2C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) antibodyGRIN2C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibodyGRIN2C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 69-118) antibodyGRIN2C 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (Internal Region) antibodyGRIN2C 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 365-377), (Extracellular), (N-Term) antibodyGRIN2C 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1244) antibodyGRIN2C 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1096) antibodyGRIN2C 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibodyGRIN2C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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Western blot: 1/1000. Immunofluorescence: 1/1000-1/2000 (Frozen Sections). Immunohistochemitry: 1/1000-1/2000 (Frozen Sections). Immunoprecipitation: 3 μL per 200 μg lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 溶解方式
- Restore in 50 μL PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.
- 缓冲液
- 5 mM Ammonium Bicarbonate.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- After reconstitution Store the antibody undiluted (in aliquots) at-20 °C.
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- 抗原
- GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
- 别名
- NMDA Receptor 2C (GRIN2C 产品)
- 背景
- The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996).Synonyms: GRIN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C
- 基因ID
- 24411
- NCBI登录号
- NP_036707
- UniProt
- Q00961
- 途径
- Synaptic Membrane
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