Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 1 μg/mL. ELISA: 1 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
0.5 mg/mL
缓冲液
PBS, 0.01 % Sodium Azide, 50 % Glycerol
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
抗原
Band 3/AE1 (SLC4A1)
(Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))
AE1 antibody, BND3 antibody, CD233 antibody, DI antibody, EMPB3 antibody, EPB3 antibody, FR antibody, RTA1A antibody, SW antibody, WD antibody, WD1 antibody, WR antibody, Ae1 antibody, Empb3 antibody, l11Jus51 antibody, ae1 antibody, band3 antibody, MGC152771 antibody, zgc:111889 antibody, zgc:152771 antibody, si:dz180g5.1 antibody, LOC100136769 antibody, slc4a1 antibody, wd1 antibody, bnd3 antibody, epb3 antibody, cd233 antibody, empb3 antibody, rta1a antibody, MGC80391 antibody, SLC4A1 antibody, BB3 antibody, EAT antibody, solute carrier family 4 member 1 (Diego blood group) antibody, solute carrier family 4 (anion exchanger), member 1 antibody, solute carrier family 4 (anion exchanger), member 1a (Diego blood group) antibody, Band 3 antibody, erythrocyte membrane protein band 4.1 like 3 antibody, solute carrier family 4 member 1 (Diego blood group) L homeolog antibody, solute carrier family 4 member 1 antibody, SLC4A1 antibody, Slc4a1 antibody, slc4a1a antibody, LOC100136769 antibody, EPB41L3 antibody, slc4a1.L antibody, slc4a1 antibody
背景
SLC4A1 (also known as Band 3 protein, Anion exchanger 1) is the most abundant integral protein of human erythrocyte membranes and functions as the major anion transporter polypeptide of erythrocytes, exchanging bicarbonate ions for chloride ions. It plays a central role in structure and function of red blood cells and in acid-secreting cells in the kidney. Band 3 is a 90-100 kD protein, its microheterogeneity is ascribed mainly to the structural heterogeneity of the carbohydrate moiety. The C-terminal portion of the molecule spans the membrane several times, and is responsible for anion transport. The N-terminal portion, comprising almost half of the polypeptide chain of Band 3, is located inside the red cell and interacts with cytoskeletal and cytoplasmic proteins such as ankyrin. There are several Band 3 mutations known in man, which cause several diseases including hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the Band 3 protein and is common in areas where Plasmodium falciparum malaria is endemic.Synonyms: AE1, Anion Exchanger 1, Anion exchange protein 1, Band 3 anion transport protein, EPB3, Solute carrier family 4 member 1