TCR gamma/delta 抗体
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- 抗原 See all TCR gamma/delta products
- TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
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适用
- 小鼠
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宿主
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仓鼠
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克隆类型
- 单克隆
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标记
- This TCR gamma/delta antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- 产品特性
- Synonyms: TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta
- 纯化方法
- Purified
- 克隆位点
- UC7-13D5
- 亚型
- IgG
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- 应用备注
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Flow Cytometry. (Ref.4-7)Immunoprecipitation. (Ref.5)Immunohistochemistry on Frozen Sections. (Ref.8)In vitro Activation of gamma-delta TCR-bearing cells. (Ref.5)In vivo Depletion of gamma-delta TCR-expressing T cells. (Ref.5)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
- 别名
- T Cell Receptor / TCR gamma/delta (TCR gamma/delta 产品)
- 背景
- T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment, a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3)Synonyms: T-Cell Receptor delta, T-Cell Receptor gamma, T-Cell Receptor gamma delta, TCRD, TCRG
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