The antibody detects endogenous level of total CREB protein and it also detects the CREB-related protein ATF-1.
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
免疫原
Peptide sequence around AA 131-135 (R-P-S-Y-R) derived from Human CREB. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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背景
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.