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- 抗原 See all Caveolin-1 (CAV1) 抗体
- Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
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抗原表位
- pTyr14
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Caveolin-1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- The antibody detects endogenous level of Caveolin-1 only when phosphorylated at tyrosine 14.
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- 免疫原
- Peptide sequence around phosphorylation site of pTyr14 (H-L-Y (p) -T-V) derived from Human CAVEOLIN-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- 亚型
- IgG
- Top Product
- Discover our top product CAV1 Primary Antibody
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- 应用备注
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Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid." in: Journal of neurochemistry, Vol. 111, Issue 1, pp. 49-60, (2009) (PubMed).
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Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid." in: Journal of neurochemistry, Vol. 111, Issue 1, pp. 49-60, (2009) (PubMed).
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- 抗原
- Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
- 别名
- Caveolin-1 (CAV1 产品)
- 别名
- fc07c04 antibody, wu:fc07c04 antibody, Cav-1 antibody, bscl3 antibody, cav1 antibody, cav1a antibody, cgl3 antibody, vip21 antibody, cav1b antibody, caveolin-1 antibody, cav antibody, mstp085 antibody, Caveolin-1 antibody, CAV1 antibody, cav-1 antibody, Cav antibody, caveolin 1 antibody, BSCL3 antibody, CGL3 antibody, MSTP085 antibody, PPH3 antibody, VIP21 antibody, caveolin 1 antibody, caveolin 1 L homeolog antibody, caveolin 1 S homeolog antibody, caveolin 1, caveolae protein antibody, caveolin 1, caveolae protein, 22kDa antibody, Caveolin antibody, cav1 antibody, cav1.L antibody, cav1.S antibody, CAV1 antibody, Cav1 antibody, cav-1 antibody
- 背景
- The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene.
- 分子量
- 24 kDa
- NCBI登录号
- NP_001166
- UniProt
- Q03135
- 途径
- Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals
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