HSP90 抗体
(5 references)-
- 抗原 See all HSP90 抗体
- HSP90 (Heat Shock Protein 90 (HSP90))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HSP90 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Detects ~90 kDa.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein A Purified
- 免疫原
- Full length protein HSP90
- Top Product
- Discover our top product HSP90 Primary Antibody
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anti-Heat Shock Protein 90 (HSP90) antibody
HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 unconjugated
anti-Heat Shock Protein 90 (HSP90) (Lys284), (Lys292) antibodyHSP90 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock Protein 90 (HSP90) antibody (HRP)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 HRP
anti-Heat Shock Protein 90 (HSP90) antibody (FITC)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 FITC
anti-Heat Shock Protein 90 (HSP90) antibody (Biotin)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 Biotin
anti-Heat Shock Protein 90 (HSP90) antibody (Atto 488)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 Atto 488
anti-Heat Shock Protein 90 (HSP90) antibody (PE)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 PE
anti-Heat Shock Protein 90 (HSP90) antibody (APC)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 APC
anti-Heat Shock Protein 90 (HSP90) antibody (PerCP)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 PerCP
anti-Heat Shock Protein 90 (HSP90) antibody (Atto 594)HSP90 适用: 人 WB, IHC, IP, ELISA, IF, ICC, AA 宿主: 小鼠 Monoclonal H9010 Atto 594
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- 应用备注
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- WB (1:500)
- IHC (1:100)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
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A 1:500 dilution of ABIN361822 was sufficient for detection of 0.2 mg of purified HSP90 by ECL immunoblot analysis.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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: "H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer." in: International journal of molecular sciences, Vol. 20, Issue 16, (2019) (PubMed).
: "Nucleoporin 153 regulates estrogen-dependent nuclear translocation of endothelial nitric oxide synthase and estrogen receptor beta in prostate cancer." in: Oncotarget, Vol. 9, Issue 46, pp. 27985-27997, (2018) (PubMed).
: "B cell-specific deficiencies in mTOR limit humoral immune responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 4, pp. 1692-703, (2013) (PubMed).
: "Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy." in: Brain : a journal of neurology, Vol. 135, Issue Pt 9, pp. 2629-41, (2012) (PubMed).
: "Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells." in: Molecular and cellular biochemistry, Vol. 358, Issue 1-2, pp. 265-80, (2011) (PubMed).
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: "H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer." in: International journal of molecular sciences, Vol. 20, Issue 16, (2019) (PubMed).
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- 抗原
- HSP90 (Heat Shock Protein 90 (HSP90))
- 别名
- HSP90 (HSP90 产品)
- 背景
- HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1-2 % of cytosolic protein). It carries out a number of housekeeping functions - including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
- 基因ID
- 3326
- NCBI登录号
- NP_031381
- UniProt
- P08238
- 途径
- M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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