(1 reference)-
- 抗原 See all FKBP5 抗体
- FKBP5 (FK506 Binding Protein 5 (FKBP5))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FKBP5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Detects ~51 kDa.
- 交叉反应
- 犬, Hamster, 人, 小鼠, 兔, 大鼠
- 纯化方法
- Protein G Purified
- 免疫原
- Synthetic peptide corresponding to the residues of human FKBP51
- 克隆位点
- Hi51B
- 亚型
- IgG1
- Top Product
- Discover our top product FKBP5 Primary Antibody
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anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibody
FKBP5 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 308-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 3D1-1B10 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D10-1G11 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 201-300) antibodyFKBP5 适用: 小鼠, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 326-375) antibodyFKBP5 适用: 人, 小鼠, 大鼠, 犬, 兔, Hamster, Cow, 马, 豚鼠, Pig, 斑马鱼, Bat, 小鸡, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibody (HRP)FKBP5 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal Hi51B HRP
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- 应用备注
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- WB (1:2000)
- ICC/IF (1:1000)
- optimal dilutions for assays should be determined by the user.
- 说明
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A 1:2000 dilution was sufficient for detection of FKBP51 in ~50 μg total protein using WB analysis.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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: "Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity." in: Journal of molecular endocrinology, (2015) (PubMed).
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: "Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity." in: Journal of molecular endocrinology, (2015) (PubMed).
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- 抗原
- FKBP5 (FK506 Binding Protein 5 (FKBP5))
- 别名
- FKBP51 (FKBP5 产品)
- 别名
- FKBP5 antibody, FKBP-5 antibody, AIG6 antibody, FKBP51 antibody, FKBP54 antibody, P54 antibody, PPIase antibody, Ptg-10 antibody, D17Ertd592e antibody, Dit1 antibody, si:zc263a23.8 antibody, wu:fc31g11 antibody, wu:fl87b03 antibody, zgc:64082 antibody, FK506 binding protein 5 antibody, FKBP5 antibody, fkbp5 antibody, Fkbp5 antibody
- 背景
- HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
- 基因ID
- 2289
- NCBI登录号
- NP_001139247
- UniProt
- Q13451
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