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FKBP4 抗体

FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C unconjugated
产品编号 ABIN361687
发货至: 中国
  • 抗原 See all FKBP4 抗体
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    适用
    • 100
    • 32
    • 16
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    宿主
    • 63
    • 35
    • 2
    小鼠
    克隆类型
    • 59
    • 41
    单克隆
    标记
    • 46
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    This FKBP4 antibody is un-conjugated
    应用范围
    • 82
    • 48
    • 37
    • 26
    • 18
    • 16
    • 15
    • 15
    • 14
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~52 kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
    交叉反应
    犬, Hamster, 人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Synthetic peptide corresponding to the residues of human FKBP52
    克隆位点
    Hi52C
    亚型
    IgG2a
    Top Product
    Discover our top product FKBP4 Primary Antibody
  • 应用备注
    • WB (1:2000)
    • IHC (1:250)
    • ICC/IF (1:1000)
    • IP (5 μg)
    • optimal dilutions for assays should be determined by the user.
    说明

    0.5 μg/ml was sufficient for detection of FKBP52 in 20 μg total protein using WB by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C
  • 抗原
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    别名
    FKBP52 (FKBP4 产品)
    别名
    HBI antibody, p52 antibody, hsp56 antibody, PPIase antibody, fkbp52 antibody, fkbp59 antibody, MGC81078 antibody, wu:fb34f09 antibody, 59kDa antibody, AL022792 antibody, AW208983 antibody, FKBP-4 antibody, FKBP-52 antibody, FKBP52 antibody, FKPB52 antibody, p59 antibody, FKBP51 antibody, FKBP59 antibody, Hsp56 antibody, P59 antibody, FK506 binding protein 4 antibody, FK506 binding protein 4 S homeolog antibody, FKBP4 antibody, fkbp4.S antibody, fkbp4 antibody, Fkbp4 antibody
    背景
    HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
    基因ID
    2288
    NCBI登录号
    NP_002005
    UniProt
    Q02790
    途径
    Intracellular Steroid Hormone Receptor Signaling Pathway
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