(1 reference)-
- 抗原 See all SYN1 抗体
- SYN1 (Synapsin I (SYN1))
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抗原表位
- pSer549
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SYN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Specific for ~78k synapsin I doublet phosphorylated at Ser549. Immunolabeling of the synapsin I band is blocked by (-phosphatase treatment.
- 交叉反应
- 大鼠
- 预测反应
- bovine, canine, human, mouse, non-human primate
- 纯化方法
- Antigen Affinity Purified from Pooled Serum
- 免疫原
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser549 conjugated to KLH
- Top Product
- Discover our top product SYN1 Primary Antibody
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anti-Synapsin I (SYN1) (AA 362-511) antibody
SYN1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, ICC, FACS, mIHC 宿主: 小鼠 Monoclonal 7H10G6 unconjugated
anti-Synapsin I (SYN1) (AA 113-420) antibodySYN1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 362-450) antibodySYN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H1 unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) antibodySYN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) antibodySYN1 适用: 人, 小鼠, 大鼠, Cow WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer62), (pSer67) antibodySYN1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 201-300) antibodySYN1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 113-420) antibodySYN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended Dilution: WB: 1:1000 IHC: 1:500 Quality Control: Western blots performed on each lot.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
- 储存条件
- -20 °C
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: "Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain." in: Journal of neuroscience research, Vol. 89, Issue 10, pp. 1646-57, (2011) (PubMed).
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: "Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain." in: Journal of neuroscience research, Vol. 89, Issue 10, pp. 1646-57, (2011) (PubMed).
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- 抗原
- SYN1 (Synapsin I (SYN1))
- 别名
- SYN1 (SYN1 产品)
- 别名
- SYN1a antibody, SYN1b antibody, SYNI antibody, Syn-1 antibody, SYN I antibody, si:dkey-90n12.3 antibody, synapsin I antibody, synapsin I L homeolog antibody, SYN1 antibody, Syn1 antibody, syn1.L antibody, syn1 antibody
- 背景
- Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking. Anti-Phospho-Ser549 Synapsin Western blot of rat cortex lysate showing specific immunolabeling of the ~78k synapsin I phosphorylated at Ser549 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho Ser549 synapsin I antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
- 分子量
- '78 kDa
- 基因ID
- 281510
- UniProt
- P17599
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