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Glutamate Receptor 1 抗体 (pSer845)

Name: Glutamate Receptor 1 抗体 (pSer845)
Brand: antibodies-online
SKU: ABIN361477
Availability: OutOfStock

GLUR1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western blots of rat hippocampal lysate showing specific immunolabeling of the ~100k GluR1 protein phosphorylated at Ser845 (Control). (Glutamate Receptor 1 抗体 (pSer845))

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100 kDa GluR1 protein phosphorylated at Ser845 in the first lane (-). (Glutamate Receptor 1 抗体 (pSer845))

2 images

(26 references)

产品编号 ABIN361477

发货至: 中国

Datasheet as PDF

抗原 See all Glutamate Receptor 1 (GLUR1) 抗体

Glutamate Receptor 1 (GLUR1)
抗原表位
18

15

15

14

14

12

12

7

6

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
pSer845
适用
111

108

95

11

6

5

4

4

4

2

2

2

1

1
大鼠
宿主
120

24

1
兔
Compatible Secondaries
克隆类型
112

33
多克隆
标记
70

8

5

5

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

1

1

1

1

1

1
This Glutamate Receptor 1 antibody is un-conjugated
应用范围
98

40

40

39

38

28

15

15

13

4

4

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

特异性

The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with human, mouse and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen. Specific for the ~100k GluR1 protein phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by treatment with λ-Ptase.

交叉反应

小鼠, 大鼠

预测反应

human, non-human primates

纯化方法

Antigen Affinity Purified from Pooled Serum

免疫原

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser845 conjugated to KLH

Top Product

Discover our top product GLUR1 Primary Antibody
anti-Glutamate Receptor 1 (GLUR1) (AA 19-300) antibody
GLUR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 19-360) antibody
GLUR1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) (C-Term) antibody
GLUR1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glutamate Receptor 1 (GLUR1) antibody
Microarray verified GLUR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB177574 unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 unconjugated

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (HRP)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 HRP

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (FITC)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 FITC

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (Biotin)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 Biotin

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (PE)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 PE

anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (PerCP)
GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 PerCP

应用备注

WB: 1:1000. IHC: 1:1000 (frozen sections).

限制

仅限研究用
状态

Liquid

缓冲液

100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

储存条件

-20 °C
Hikida, Morita, Kuroiwa, Macpherson, Shuto, Sotogaku, Niwa, Sawa, Nishi: "Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice." in: Neuroscience research, Vol. 151, pp. 38-45, (2020) (PubMed).

Mao, Wang: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." in: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).

Musante, Li, Kanyo, Lam, Colangelo, Cheng, Brody, Greengard, Le Novère, Nairn: "Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Hollis, Sevelinges, Grosse, Zanoletti, Sandi: "Involvement of CRFR1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit." in: eNeuro, Vol. 3, Issue 5, (2017) (PubMed).

Zhang, Fu, Fu, Ip: "S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength." in: Nature communications, Vol. 6, pp. 8665, (2016) (PubMed).

Ip, Fu, Cheng, Tong, Lok, Liang, Ye, Ip: "Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 40, Issue 8, pp. 1877-87, (2015) (PubMed).

Mao, Xue, Jin, Wang: "Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine." in: Journal of neurochemistry, Vol. 133, Issue 6, pp. 795-805, (2015) (PubMed).

Suzuki, Harada, Shiraishi, Kimura: "In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 471-9, (2015) (PubMed).

Tassin, Benavides, Plattner, Nishi, Bibb: "Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain." in: The Journal of biological chemistry, Vol. 290, Issue 26, pp. 16319-29, (2015) (PubMed).

Mao, Hastings, Fibuch, Wang: "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice." in: European journal of pharmacology, Vol. 738, pp. 237-44, (2014) (PubMed).

Wang, Zhang, Xu, Zhu, Wang, He, Zhang, Guo, Kong, Huang, Li: "Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice." in: Current Alzheimer research, Vol. 11, Issue 7, pp. 672-80, (2014) (PubMed).

Bernard, Castano, Bayer, Benke: "Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures." in: Neuropharmacology, Vol. 84, pp. 1-12, (2014) (PubMed).

Xue, Edwards, Mao, Guo, Jin, Fibuch, Wang: "Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration." in: Neurochemistry international, Vol. 64, pp. 48-54, (2013) (PubMed).

Shen, Fu, Cheng, Fu, Ip: "Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 2, pp. 464-72, (2013) (PubMed).

Davis, Olausson, Greengard, Taylor, Nairn: "Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits." in: The European journal of neuroscience, Vol. 35, Issue 2, pp. 300-8, (2012) (PubMed).

Ferrario, Loweth, Milovanovic, Wang, Wolf: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." in: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, (2011) (PubMed).

Kuroiwa, Snyder, Shuto, Fukuda, Yanagawa, Benavides, Nairn, Bibb, Greengard, Nishi: "Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex." in: Psychopharmacology, (2011) (PubMed).

Torres-Altoro, Mathur, Drerup, Thomas, Lovinger, OCallaghan, Bibb: "Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum." in: Journal of neurochemistry, Vol. 119, Issue 2, pp. 303-13, (2011) (PubMed).

Ferrario, Loweth, Milovanovic, Ford, Galiñanes, Heng, Tseng, Wolf: "Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²?-permeable AMPA receptors during the incubation of cocaine craving." in: Neuropharmacology, Vol. 61, Issue 7, pp. 1141-51, (2011) (PubMed).

Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

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抗原

Glutamate Receptor 1 (GLUR1)

别名

GRIA1 (GLUR1 产品)

别名

GLUH1 antibody, GLUR1 antibody, GLURA antibody, GluA1 antibody, HBGR1 antibody, gluR-A antibody, 2900051M01Rik antibody, Glr-1 antibody, Glr1 antibody, GluR-A antibody, GluRA antibody, Glur-1 antibody, Glur1 antibody, HIPA1 antibody, gluR-K1 antibody, GRIA1 antibody, glur1 antibody, Gria1 antibody, glur1b antibody, gria1.2 antibody, sb:eu293 antibody, ZfGluR1a antibody, glur1a antibody, gria1.1 antibody, zfGRIA1[a] antibody, glutamate ionotropic receptor AMPA type subunit 1 antibody, glutamate receptor, ionotropic, AMPA1 (alpha 1) antibody, glutamate receptor, ionotropic, AMPA 1 antibody, glutamate receptor, ionotropic, AMPA 1 L homeolog antibody, GluR1 protein antibody, Glutamate receptor 1 antibody, glutamate receptor, ionotropic, AMPA 1b antibody, glutamate receptor, ionotropic, AMPA 1a antibody, GRIA1 antibody, Gria1 antibody, gria1 antibody, gria1.L antibody, glur1 antibody, glr-1 antibody, gria1b antibody, gria1a antibody

背景

Affinity purified rabbit polyclonal antibody. Biological Significance: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as arning and memory (Lee at al., 2003; Esteban at al., 2003).

分子量

'100 kDa

基因ID

50592

UniProt

P19490

途径

PI3K-Akt Signaling