-
- 抗原 See all GABRA3 抗体
- GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
-
抗原表位
- N-Term
-
适用
- 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This GABRA3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Specific for the ~51k a3-subunit of the GABAA receptor in Western blots. Labeling is absent in a3-subunit knockout animals.
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- bovine, canine, human, non-human primates, Zebrafish
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Synthetic peptide from the N-terminal region of the alpha 3 subunit
- Top Product
- Discover our top product GABRA3 Primary Antibody
-
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibody
GABRA3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibodyGABRA3 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 29-43) antibodyGABRA3 适用: 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 480-492) antibodyGABRA3 适用: 人, 大鼠, 小鼠, Cow, 兔, 马, 猴, Bat, Hamster IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (N-Term) antibodyGABRA3 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (C-Term) antibodyGABRA3 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (Middle Region) antibodyGABRA3 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 29-43), (Extracellular), (N-Term) antibodyGABRA3 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF, IP, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibodyGABRA3 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 28-61), (N-Term) antibodyGABRA3 适用: 人 WB 宿主: 兔 Polyclonal RB50699 unconjugated
-
- 应用备注
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
- 储存条件
- -20 °C
-
- 抗原
- GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
- 别名
- GABRA3 (GABRA3 产品)
- 别名
- GABRA3 antibody, Gabra-3 antibody, si:ch211-113k9.1 antibody, gamma-aminobutyric acid type A receptor alpha3 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 3 antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 antibody, gamma-aminobutyric acid receptor subunit alpha-3 antibody, GABRA3 antibody, gabra3 antibody, Gabra3 antibody, LOC100653496 antibody
- 背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, fourbetas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and gamma-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA-Receptor, 3 -Subunit Western blot of mouse brain lysates from wild type (Control) and a3-knockout (aK/O) animals showing specific immunolabeling of the ~51k a3-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a3-knockout animals.
- 分子量
- '51 kDa
- 基因ID
- 24947
- UniProt
- P20236
-
You are here:
