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- 抗原 See all Peripherin (PRPH) 抗体
- Peripherin (PRPH)
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适用
- 大鼠
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宿主
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小鸡
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克隆类型
- 多克隆
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标记
- This Peripherin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- Specific for the ~57kDa peripherin protein.
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- most mammalian
- 纯化方法
- Total IgY fraction
- 免疫原
- Recombinant rat peripherin expressed in and purified from E. coli
- Top Product
- Discover our top product PRPH Primary Antibody
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- 应用备注
- Recommended Dilution: WB:1:1,000 IF: 1:500 Quality Control: Western blots performed on each lot.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- total IgY fraction in PBS + 10 mM Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors." in: eLife, Vol. 6, (2018) (PubMed).
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Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors." in: eLife, Vol. 6, (2018) (PubMed).
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- 抗原
- Peripherin (PRPH)
- 别名
- PRPH (PRPH 产品)
- 别名
- NEF4 antibody, PRPH1 antibody, Prph1 antibody, Perf antibody, nef4 antibody, prph1 antibody, MGC69454 antibody, if3 antibody, plasticin antibody, zgc:111926 antibody, peripherin antibody, peripherin L homeolog antibody, PRPH antibody, Prph antibody, prph antibody, prph.L antibody
- 背景
- Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.
- 分子量
- '57 kDa
- 基因ID
- 3414
- UniProt
- P21807
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