MAP2 抗体
(5 references)Quick Overview for MAP2 抗体 (ABIN361345)
抗原
See all MAP2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Specific for the ~ 280k MAP2 protein.
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交叉反应
- 牛, 人, 小鼠, 大鼠
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灵敏度
- The antibody has been directly tested for reactivity in bovine, human, mouse and rat. It is expected that the antibody will react with other mammalian tissues.
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纯化方法
- Total IgY fraction
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免疫原
- recombinant bovine MAP2 protein expressed in and purified from E. Coli
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anti-Microtubule-Associated Protein 2 (MAP2) (AA 260-559) antibody
MAP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: 人, 小鼠, Pig WB, ELISA, ICC, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal MT-08 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 350-400) antibodyMAP2 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMicroarray verified MAP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB573626 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (N-Term) antibodyMAP2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 727-985) antibodyMAP2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 1459-1718) antibodyMAP2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMicroarray verified MAP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB2355 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMicroarray verified MAP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB146071 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated
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应用备注
- Recommended Dilution: WB: 1:20,000 IF: 1:2,500 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- total IgY fraction in PBS + 10 mM Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders." in: Scientific reports, Vol. 12, Issue 1, pp. 902, (2022) (PubMed).
: "Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans." in: Molecular psychiatry, (2022) (PubMed).
: "Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus." in: Molecular autism, Vol. 11, Issue 1, pp. 85, (2021) (PubMed).
: "Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear β-catenin signaling." in: Journal of neurochemistry, (2020) (PubMed).
: "GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons." in: Molecular and cellular neurosciences, Vol. 61, pp. 1-12, (2014) (PubMed).
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: "Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders." in: Scientific reports, Vol. 12, Issue 1, pp. 902, (2022) (PubMed).
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- MAP2 (Microtubule-Associated Protein 2 (MAP2))
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别名
- MAP2
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背景
- Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein ( (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein ( (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (Fontaine-Lenore V. et al., 2006). Anti-MAP2 Left: Western blot of rat cortex lysate showing specific immunolabeling of the ~280k MAP2 protein. Right:Mixed neuron/glial cultures. The perikarya and dendrites of neurons are strongly and specifically stained with the MAP2 antibody (red). Cell nuclei are visualized with DAPI DNA stain.
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分子量
- '280 kDa
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基因ID
- 4133
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UniProt
- P11137
抗原
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