Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
免疫原
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (between 20-50aa) of human AMHR2.
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth, anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.Synonyms: AMH type II receptor, Anti-Muellerian hormone type II receptor, Anti-Muellerian hormone type-2 receptor, MIS type II receptor, MISRII