ELISA: 1/1,000. Western blotting: 1/10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
状态
Liquid
浓度
0.25 mg/mL
缓冲液
PBS with 0.09 % (W/V) sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
抗原
PARP6
(Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6))
ARTD17 antibody, PARP-6-B1 antibody, PARP-6-C antibody, pART17 antibody, 1700119G14Rik antibody, 2310028P13Rik antibody, 3110038K10Rik antibody, C030013N01Rik antibody, PARP-6 antibody, RGD1310937 antibody, zgc:92798 antibody, poly(ADP-ribose) polymerase family member 6 antibody, poly (ADP-ribose) polymerase family, member 6 antibody, poly(ADP-ribose) polymerase family member 6 S homeolog antibody, poly [ADP-ribose] polymerase 6 antibody, poly (ADP-ribose) polymerase family, member 6a antibody, PARP6 antibody, Parp6 antibody, parp6 antibody, parp6.S antibody, LOC100475149 antibody, parp6a antibody
背景
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.Synonyms: PARP-6, Poly [ADP-ribose] polymerase 6