A working concentration of 5-15 µg/ml is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections. The optimal working solution should be determined by the end user.
限制
仅限研究用
状态
Lyophilized
溶解方式
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
注意事项
Avoid freeze and thaw cycles.
储存条件
4 °C/-20 °C
储存方法
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR.