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Choline Acetyltransferase 抗体 (AA 590-640)

Name: Choline Acetyltransferase 抗体 (AA 590-640)
Brand: antibodies-online
SKU: ABIN350213
Availability: OutOfStock

CHAT 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

(1 reference)

产品编号 ABIN350213

发货至: 中国

Datasheet as PDF

抗原 See all Choline Acetyltransferase (CHAT) 抗体

Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))
抗原表位
16

15

6

6

2

2

2

2

1

1

1

1
AA 590-640
适用
71

46

41

17

5

2

2

1

1
小鼠, 大鼠
宿主
65

5

5

4

3
兔
Compatible Secondaries
克隆类型
70

12
多克隆
标记
40

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Choline Acetyltransferase antibody is un-conjugated
应用范围
42

22

21

20

16

14

13

13

7

5

4

3

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

特异性

Specific for ChAT.

交叉反应（详细）

May contain small amounts of intact IgG

纯度

> 90 % based on SDS-PAGE

免疫原

A synthetic peptide from aa regio 590-640 of mouse ChAT conjugated to an immunogenic carrier protein was used as the antigen.

亚型

IgG

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anti-Choline O-Acetyltransferase (CHAT) antibody
Microarray verified CHAT 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB872084 unconjugated

anti-Choline O-Acetyltransferase (CHAT) (C-Term) antibody
CHAT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.

限制

仅限研究用
状态

Lyophilized

溶解方式

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

注意事项

Avoid freeze and thaw cycles.

储存条件

4 °C/-20 °C

储存方法

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

有效期

12 months
Wang, Wu, Wu, Sun, Zhang, Deng, Walker, Qu, Chen, Liu, Han, Dai, Shields, Shields, Sengelaub, Jones, Smith, Xu: "Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery." in: eLife, Vol. 7, (2019) (PubMed).
抗原

Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

别名

ChAT (CHAT 产品)

别名

CHOACTASE antibody, CMS1A antibody, CMS1A2 antibody, ChoAcTase antibody, B230380D24Rik antibody, choline O-acetyltransferase antibody, choline O-acetyltransferase a antibody, choline acetyltransferase antibody, carnitine O-acetyltransferase antibody, CHAT antibody, chata antibody, Chat antibody, PGTG_00551 antibody, LOC100533322 antibody

背景

Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein. Choline acetylase catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Catalytic activity: Acetyl-CoA + choline = CoA + O-acetylcholine. Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2), also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive. Also known as: CHOACTase, choline acetylase, choline O-acetyltransferase, CMS1A, CMS1A2, B230380D24Rik.

途径

Skeletal Muscle Fiber Development