ASIC1 抗体 (Extracellular Domain)
(2 references)-
- 抗原 See all ASIC1 (ACCN2) 抗体
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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抗原表位
- Extracellular Domain
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适用
- 大鼠
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宿主
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绵羊
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克隆类型
- 多克隆
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标记
- This ASIC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Specific for ASIC1.
- 交叉反应
- 人, 小鼠, 大鼠
- 交叉反应 （详细）
- Other species not yet tested.
- 纯化方法
- IgG
- 免疫原
- A synthetic peptide from the extracellular domain of rat ACCN2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and shares 96% identity with human's.
- 亚型
- IgG
- Top Product
- Discover our top product ACCN2 Primary Antibody
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anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) antibody
ACCN2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (C-Term) antibodyVerified ACCN2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibodyACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (HRP)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 HRP
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (FITC)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 FITC
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (Alkaline Phosphatase (AP))ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 Alkaline Phosphatase (AP)
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (Biotin)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 Biotin
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (PE)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 PE
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (APC)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 APC
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (PerCP)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 PerCP
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- 应用备注
- IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- 注意事项
- Avoid freeze and thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- 有效期
- 12 months
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: "Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer." in: Frontiers in oncology, Vol. 12, pp. 904742, (2022) (PubMed).
: "Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis." in: Biomedicines, Vol. 9, Issue 10, (2021) (PubMed).
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: "Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer." in: Frontiers in oncology, Vol. 12, pp. 904742, (2022) (PubMed).
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- 抗原
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
- 别名
- ACCN2 (ACCN2 产品)
- 别名
- ACCN2 antibody, ASIC antibody, BNaC2 antibody, Accn2 antibody, ASIC1 antibody, AI843610 antibody, ASIC1a antibody, B530003N02Rik antibody, acid sensing ion channel subunit 1 antibody, acid-sensing (proton-gated) ion channel 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, ASIC1 antibody, Asic1 antibody, asic1 antibody, SMARCD1 antibody
- 背景
- This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit, however, its function as an ion channel remains unknown. FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Note=Localizes in synaptosomes at dendritic synapses of neurons. TISSUE SPECIFICITY: Expressed in dorsal root ganglia (DRG) and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed in olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.,ACCN Channels,Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, ACCN2
- UniProt
- P55926
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