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SERPINB2 抗体 (Internal Region)

Name: SERPINB2 抗体 (Internal Region)
Brand: antibodies-online
SKU: ABIN349627
Availability: OutOfStock

SERPINB2 适用: 人, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot using affinity purified anti-PAI-2 antibody shows detection of endogenous PAI-2 in 50 µg of HeLa whole cell lysates. (SERPINB2 抗体 (Internal Region))

Immunohistochemistry of rabbit anti-Plasminogen Activator 2 antibody (ABIN349627). (SERPINB2 抗体 (Internal Region))

IHC (p)

2 images

(1 reference)

产品编号 ABIN349627

发货至: 中国

Datasheet as PDF

抗原 See all SERPINB2 抗体

SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
抗原表位
15

6

4

3

2

2

2

1

1

1

1

1

1

1

1

1
Internal Region
适用
47

12

9

3

3

2

2

2

2

1
人, 猴
宿主
46

8

1

1
兔
Compatible Secondaries
克隆类型
50

5
多克隆
标记
29

4

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This SERPINB2 antibody is un-conjugated
应用范围
29

17

13

13

12

7

7

6

4

3

2

1

1

1
Western Blotting (WB), ELISA

特异性

This affinity-purified antibody is directed against human PAI-2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity occurs against human PAI-2 protein. A BLAST analysis was used to suggest cross reactivity with PAI-2 proteins from several primates based on 94% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

交叉反应

猴

产品特性

Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60-kDa, secreted, extracellular, glycosylated form and a 43-kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.

纯化方法

affinity purified

过滤

Sterile filtered

免疫原

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human PAI-2 protein.
Immunogen Type: Peptide

亚型

IgG

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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (Center) antibody
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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 154-408) antibody
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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 1-100) antibody
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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 154-408) antibody
SERPINB2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 293-389) antibody
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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 1-415) antibody
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anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (Internal Region) antibody
SERPINB2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 170-393) antibody
SERPINB2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Plasminogen Activator Inhibitor 2 (SERPINB2) (AA 116-144) antibody
SERPINB2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB19097 unconjugated

应用备注

This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to PAI-2 protein by western blotting in the appropriate cell lysate or extract.

说明

Gene Name: SERPINB2

限制

仅限研究用
状态

Liquid

浓度

1.2 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

有效期

3 months
Godtfredsen, Sidelmann, Dolleris, Jørgensen, Johansen, Pedersen, Palarasah, Gram: "Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).
抗原

SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

别名

Plasminogen Activator Inhibitor 2 (SERPINB2 产品)

别名

HsT1201 antibody, PAI antibody, PAI-2 antibody, PAI2 antibody, PLANH2 antibody, SERPINB2 antibody, Planh2 antibody, ovalbumin antibody, Pai2a antibody, serpin family B member 2 antibody, serpin peptidase inhibitor, clade B (ovalbumin), member 2 antibody, serine (or cysteine) peptidase inhibitor, clade B, member 2 antibody, SERPINB2 antibody, Serpinb2 antibody

物质类

Amino Acid

背景

Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor; Monocyte Arg-serpin; Urokinase inhibitor; SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60-kDa, secreted, extracellular, glycosylated form and a 43-kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.
Synonyms: PAI-2, Placental plasminogen activator inhibitor; Monocyte Arg-serpin; Urokinase inhibitor; SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2

基因ID

5055, 4505595

UniProt

P05120

途径

Autophagy