TRIM29 抗体 (Internal Region)
(2 references)-
- 抗原 See all TRIM29 抗体
- TRIM29 (Tripartite Motif Containing 29 (TRIM29))
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抗原表位
- Internal Region
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适用
- 人, Cow, 马, Macaque, Chimpanzee
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRIM29 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with over-expressed, acetylated lysine ATDC protein. A BLAST analysis was used to suggest cross-reactivity with ATDC from human, horse, cattle, chimpanzee and macaque based on a 100% homology with the immunizing sequence. Partial reactivity is expected against rat and mouse ATDC based on 92% homology with the immunizing sequence. Cross-reactivity with ATDC from other sources has not been determined.
- 交叉反应
- 马, 绵羊, Chimpanzee, Macaque
- 产品特性
- Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.
- 纯化方法
- affinity purified
- 过滤
- Sterile filtered
- 免疫原
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This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of human ATDC protein around lysine 116.
Immunogen Type: Peptide - 亚型
- IgG
- Top Product
- Discover our top product TRIM29 Primary Antibody
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anti-Tripartite Motif Containing 29 (TRIM29) (AA 451-588) antibody
TRIM29 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8C8G5 unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (Internal Region) antibodyVerified TRIM29 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 1-200) antibodyTRIM29 适用: 人 ELISA, IHC, Coat, StM 宿主: 小鼠 Monoclonal TRIM29-1041 unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (Internal Region) antibodyTRIM29 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 1-200) antibodyTRIM29 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-629M unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 309-588) antibodyTRIM29 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 1-588) antibodyTRIM29 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 1-200) antibodyTRIM29 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal TRIM29-1042 unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (C-Term) antibodyTRIM29 适用: 人, 小鼠, 大鼠, Cow, 马, 豚鼠, 犬, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 29 (TRIM29) (AA 253-283) antibodyTRIM29 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity and detection of ATDC Ac-K116 should be optimized by the end user. Expect a band approximately ~66 kDa in size corresponding to ATDC Ac-K116 by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: TRIM29
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.67 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
- 有效期
- 3 months
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: "Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39329-38, (2011) (PubMed).
: "The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions." in: Molecular and cellular biology, Vol. 30, Issue 12, pp. 3004-15, (2010) (PubMed).
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: "Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39329-38, (2011) (PubMed).
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- 抗原
- TRIM29 (Tripartite Motif Containing 29 (TRIM29))
- 别名
- ATDC Ac-K116 (TRIM29 产品)
- 别名
- ATDC antibody, 1110047J21Rik antibody, 2810431N19Rik antibody, 4732461M22Rik antibody, AI119726 antibody, MGC53484 antibody, TRIM29 antibody, atdc antibody, tripartite motif containing 29 antibody, tripartite motif-containing 29 antibody, tripartite motif containing 29 L homeolog antibody, TRIM29 antibody, Trim29 antibody, trim29.L antibody, trim29 antibody
- 背景
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Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.
Synonyms: Ataxia-telangiectasia group D associated protein antibody, ATDC antibody, FLJ36085 antibody, TRIM 29 antibody, Tripartite motif containing protein 29 antibody - 基因ID
- 23650, 17402909
- UniProt
- Q14134
- 途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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