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POGZ 抗体 (N-Term)

POGZ 适用: 人, 大鼠, 犬, Cow, 小鸡, Chimpanzee, Macaque, Olive Baboon, Opossum WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN349593
发货至: 中国
  • 抗原 See all POGZ 抗体
    POGZ (Pogo Transposable Element with ZNF Domain (POGZ))
    抗原表位
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    N-Term
    适用
    • 27
    • 12
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    人, 大鼠, 犬, Cow, 小鸡, Chimpanzee, Macaque, Olive Baboon, Opossum
    宿主
    • 26
    • 2
    克隆类型
    • 28
    多克隆
    标记
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This POGZ antibody is un-conjugated
    应用范围
    • 16
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    特异性
    This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.  This antibody is known to react with mouse Pogz protein.  A BLAST analysis was used to suggest cross-reactivity with Pogz from human, dog, short-tailed opossum, cattle, rat, chimpanzee, macaque, olive baboon, and chicken sources based on 100% homology with the immunizing sequence.    Reactivity with Pogz from other sources has not been determined.
    交叉反应
    犬, Opossum (Didelphimorphia), 绵羊, 大鼠, Chimpanzee, Macaque, Olive Baboon, 小鸡
    产品特性
    This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Pogz is a zinc-finger protein containing at least 8 C2H2 zinc fingers, a CENP-B (centromere protein-B) domain, and a DDE domain found in the bacterial transposase/retroviral integrase family. Members of this family of integrases share structural homologies and show similar catalytic activity to the RAG1 and RAG2 proteins that initiate V(D)J recombination in lymphoid progenitors. Mouse Pogz has a human homolog with a base pair similarity of 90% and amino acid similarity of 93% for the full length protein. In humans at least 3 variants have been predicted and they are all similar at the N-terminus. A number of expressed sequence tags (ESTs) cloned from murine undifferentiated ES cells and Lin-/c-Kit+/Sca-1+ hematopoietic stem cell cDNA libraries correspond to the Pogz gene, further underlining an important function for this gene in stem cells. In mice, deletion of the gene in all tissues early in embryogenesis has been shown to be lethal.
    纯化方法
    affinity purified
    过滤
    Sterile filtered
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of mouse Pogz protein.
    Immunogen Type: Peptide
    亚型
    IgG
    Top Product
    Discover our top product POGZ Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 155 kDa in size corresponding to Pogz by western blotting in the appropriate cell lysate or extract.
    说明

    Gene Name: POGZ

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.6 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
    有效期
    3 months
  • 抗原
    POGZ (Pogo Transposable Element with ZNF Domain (POGZ))
    别名
    Pogz (POGZ 产品)
    别名
    POGZ antibody, ZNF280E antibody, ZNF635 antibody, ZNF635m antibody, 9530006B08Rik antibody, AU015913 antibody, AU044539 antibody, pogo transposable element with ZNF domain antibody, pogo transposable element derived with ZNF domain antibody, POGZ antibody, pogz antibody, Pogz antibody
    背景
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Pogz is a zinc-finger protein containing at least 8 C2H2 zinc fingers, a CENP-B (centromere protein-B) domain, and a DDE domain found in the bacterial transposase/retroviral integrase family. Members of this family of integrases share structural homologies and show similar catalytic activity to the RAG1 and RAG2 proteins that initiate V(D)J recombination in lymphoid progenitors.  Mouse Pogz has a human homolog with a base pair similarity of 90% and amino acid similarity of 93% for the full length protein.  In humans at least 3 variants have been predicted and they are all similar at the N-terminus.   A number of expressed sequence tags (ESTs) cloned from murine undifferentiated ES cells and Lin-/c-Kit+/Sca-1+ hematopoietic stem cell cDNA libraries correspond to the Pogz gene, further underlining an important function for this gene in stem cells.  In mice, deletion of the gene in all tissues early in embryogenesis has been shown to be lethal.
    Synonyms: pogo transposable element with ZNF domain antibody, putative protein product of Nbla00003 antibody, SUHW5 antibody, suppressor of hairy wing homolog antibody, zinc finger protein 280E antibody
    基因ID
    229584
    UniProt
    Q8BZH4
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