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EGFR 抗体 (Tyr1173)
EGFR
适用: 人
WB, FACS, IP
宿主: 小鼠
Monoclonal
EM-13
unconjugated
EGFR抗体详情
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抗原
See all EGFR 抗体
EGFR
(Epidermal Growth Factor Receptor (EGFR))
抗原表位
All epitopes for EGFR 抗体
Tyr1173
适用
All reactivities for EGFR 抗体
人
宿主
All hosts for EGFR 抗体
小鼠
克隆类型
All clonalities for EGFR 抗体
单克隆
标记
All conjugates for EGFR 抗体
This EGFR antibody is un-conjugated
应用范围
All applications for EGFR 抗体
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
特异性
The mouse monoclonal antibody EM-13 reacts with human EGFR (ErbB1 / HER1) phosphorylated on intracellular tyrosine 1173.
交叉反应 (详细)
Human
纯化方法
Purified by protein-A affinity chromatography.
纯度
> 95 % (by SDS-PAGE)
免疫原
Synthetic phospho-peptide covering sequence around tyrosine 1173 of human EGFR.
克隆位点
EM-13
亚型
IgG1
Top Product
Discover our top product EGFR Primary Antibody
Alternatives
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anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR
适用: 人, 小鼠, 大鼠, 猴, Pig, Cow, 小鸡, 犬, 马, 兔, 豚鼠, Avian, Cat, 驴, 山羊, Hamster, 绵羊
WB
宿主: 山羊
Polyclonal
unconjugated
使用细节
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应用备注
Western blotting: Recommended dilution: 1 μg/mL, positive control: EGF-stimulated A431, negative control: non-stimulated A431. Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
限制
仅限研究用
贮存及处理
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浓度
1 mg/mL
缓冲液
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Do not freeze.
储存条件
4 °C
储存方法
Store at 2-8°C. Do not freeze.
EGFR目标详情
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抗原
EGFR
(Epidermal Growth Factor Receptor (EGFR))
别名
EGFR (EGFR 产品 )
别名
C-erb antibody, CG10079 antibody, D-EGFR antibody, D-Egf antibody, DEGFR antibody, DER antibody, DER flb antibody, DER/EGFR antibody, DER/faint little ball antibody, DER/top antibody, DER/torpedo antibody, DER1 antibody, DEgfr antibody, Degfr antibody, Der antibody, DmHD-33 antibody, Dmel\\CG10079 antibody, EFG-R antibody, EGF-R antibody, EGFR antibody, EGFr antibody, EGfr antibody, EK2-6 antibody, Egf antibody, Egf-r antibody, EgfR antibody, El antibody, Elp antibody, Elp-1 antibody, Elp-B1 antibody, Elp-B1RB1 antibody, HD-33 antibody, TOP antibody, Torpedo/DER antibody, Torpedo/Egfr antibody, c-erbB antibody, d-egf-r antibody, dEGFR antibody, dEGFR1 antibody, dEgfr antibody, der antibody, egfr antibody, flb antibody, l(2)05351 antibody, l(2)09261 antibody, l(2)57DEFa antibody, l(2)57EFa antibody, l(2)57Ea antibody, mor1 antibody, top antibody, top/DER antibody, top/flb antibody, torpedo/Egfr antibody, torpedo/egfr antibody, EGFR12 antibody, EGFR15 antibody, egfr1 antibody, Erbb2 antibody, ERBB antibody, ERBB1 antibody, HER1 antibody, PIG61 antibody, mENA antibody, ErbB-1 antibody, Errp antibody, 9030024J15Rik antibody, AI552599 antibody, Erbb antibody, Errb1 antibody, Wa5 antibody, wa-2 antibody, wa2 antibody, epidermal growth factor receptor antibody, Epidermal growth factor receptor antibody, epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody, EGFR antibody, Egfr antibody, egfra antibody, egfr1 antibody, LOC5564544 antibody
背景
Epidermal growth factor receptor,The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.,EGFR, EGF-R, Her1, ERBB1, PIG61, NISBD2
基因ID
1956
UniProt
P00533
途径
NF-kappaB Signaling , RTK signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Stem Cell Maintenance , Hepatitis C , Positive Regulation of Response to DNA Damage Stimulus , Interaction of EGFR with phospholipase C-gamma , Thromboxane A2 Receptor Signaling , EGFR Downregulation , S100 Proteins
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