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- 抗原 See all LBP 抗体
- LBP (Lipopolysaccharide Binding Protein (LBP))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LBP antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.
- 交叉反应
- 牛, 犬, 马, 兔
- 纯化方法
- Protein A affinity column
- 免疫原
- native human LBP
- 克隆位点
- BiG42
- 亚型
- IgG1
- Top Product
- Discover our top product LBP Primary Antibody
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- 应用备注
- ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with bidistilled water
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.12
- 储存液
- Without preservative
- 储存条件
- -20 °C,-80 °C
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The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).
: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." in: Veterinary immunology and immunopathology, (2010) (PubMed).
: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." in: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, (2004) (PubMed).
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The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).
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- 抗原
- LBP (Lipopolysaccharide Binding Protein (LBP))
- 别名
- Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP 产品)
- 别名
- BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody
- 背景
- Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.
- 分子量
- ~58kDa
- 基因ID
- 3929
- NCBI登录号
- NP_004130
- UniProt
- P18428
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
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