8-OHDG 抗体
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北京 101111
Quick Overview for 8-OHDG 抗体 (ABIN335420)
抗原
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- 8-OHDG in all species. No observable crossreactivity for the following analogues: guanosine (G), 7methylG, 6SHG, 8bromoG, dA, dC, dT, dI, dU, dG, O6methyldG, 8OHdA, guanine (Gua), O6methylGua, 8OHGua, uric acid, Urea, creatine, creatinine Slight but minimal (<1 %) crossreactivity for the following analogues: 8sulfhydrylG and 8OHG 1
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纯化方法
- Prepared as ascites then ammonium sulphate purified
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免疫原
- 8-OHdG-conjugated Keyhole Limpet Hemocyanin
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亚型
- IgG1 kappa
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anti-8-Hydroxyguanosine (8-OHDG) antibody
8-OHDG ELISA, IHC 宿主: 小鼠 Monoclonal N45-1 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG ELISA, IHC, IP, FACS, FM 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG IHC (p), EIA, IHC (fro) 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG ELISA, IHC, WB 宿主: 小鼠 Monoclonal 15A3 unconjugated
anti-8-Hydroxyguanosine (8-OHDG) antibody8-OHDG IHC (p), EIA, IF 宿主: 小鼠 Monoclonal N45-1 unconjugated
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应用备注
- Tested for IHC and ELISA. User should determine optimum titer for each application.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized as 100 ug/mL IgG in10 mM Phosphate buffered saline, pH7.4 containing 1.0 % BSA.
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储存条件
- -20 °C
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: "Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat." in: PLoS ONE, Vol. 5, Issue 9, pp. e12606, (2010) (PubMed).
: "Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease." in: Free radical biology & medicine, Vol. 46, Issue 4, pp. 492-501, (2009) (PubMed).
: "Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 2, pp. 424-32, (2009) (PubMed).
: "Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue." in: International journal of molecular medicine, Vol. 24, Issue 1, pp. 17-22, (2009) (PubMed).
: "Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica)." in: Reproduction (Cambridge, England), Vol. 138, Issue 2, pp. 279-87, (2009) (PubMed).
: "Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty." in: Fibrogenesis & tissue repair, Vol. 2, Issue 1, pp. 5, (2009) (PubMed).
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: "Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 28, Issue 6, pp. 841-55, (2008) (PubMed).
: "Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism." in: Endocrinology, Vol. 149, Issue 8, pp. 3980-8, (2008) (PubMed).
: "Lifelong running reduces oxidative stress and degenerative changes in the testes of mice." in: The Journal of endocrinology, Vol. 199, Issue 2, pp. 333-41, (2008) (PubMed).
: "Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice." in: PLoS ONE, Vol. 3, Issue 9, pp. e3119, (2008) (PubMed).
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: "Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits." in: Biological & pharmaceutical bulletin, Vol. 35, Issue 4, pp. 494-502, (2012) (PubMed).
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- 8-OHDG (8-Hydroxyguanosine (8-OHDG))
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别名
- 8 Hydroxyguanosine (8-OHDG)
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物质类
- Chemical
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背景
- 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for 8-OHdG, and is suitable for immunohistochemistry. Cross reactivity have been checked for 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).
抗原
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