Selectin E/CD62e 抗体
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- 抗原 See all Selectin E/CD62e (SELE) 抗体
- Selectin E/CD62e (SELE) (Selectin E (SELE))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This Selectin E/CD62e antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)
- 特异性
- Mouse.
- 纯化方法
- Purified
- 免疫原
- UZ5 is a rat monoclonal IgG2b antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a Lewis rat immunized with LPS-activated mlEND1 cells expressing E-selectin at their cell surface.
- 克隆位点
- UZ5
- 亚型
- IgG2b
- Top Product
- Discover our top product SELE Primary Antibody
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anti-Selectin E (SELE) (AA 501-612) antibody
SELE 适用: 人, Pig, 小鼠, 大鼠 WB, ELISA, FACS, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 22-230) antibodySELE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (N-Term) antibodySELE 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 108-238) antibodySELE 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 260-420) antibodySELE 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) antibodySELE 适用: 人 ELISA 宿主: 小鼠 Monoclonal B-P7 unconjugated
anti-Selectin E (SELE) (AA 81-130) antibodySELE 适用: 人, Pig, 小鼠, 猴, 豚鼠, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 1-610) antibodySELE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- UZ5 recognizes a conformational epitope in the CR1 region in murine E-selectin. UZ5 partially inhibits leukocyte adhesion to murine activated endothelial cells. UZ5 is suitable for immunoblotting, ELISA, immunoprecipitation, immunohistochemistry on fozen sections and flow cytometry (dilution 1:200).
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion." in: Experimental cell research, Vol. 269, Issue 2, pp. 266-74, (2001) (PubMed).
: "Adhesion of leukocytes to the inflammed endothelium." in: Scandinavian journal of rheumatology. Supplement, Vol. 101, pp. 107-9, (1995) (PubMed).
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: "Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion." in: Experimental cell research, Vol. 269, Issue 2, pp. 266-74, (2001) (PubMed).
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- 抗原
- Selectin E/CD62e (SELE) (Selectin E (SELE))
- 别名
- E-selectin (SELE 产品)
- 别名
- SELE antibody, CD62E antibody, ELAM antibody, ELAM1 antibody, ESEL antibody, LECAM2 antibody, E-selectin antibody, Elam antibody, selectin E antibody, selectin, endothelial cell antibody, SELE antibody, Sele antibody
- 背景
- Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkappaB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
- 途径
- Thromboxane A2 Receptor Signaling
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