(9 references)-
- 抗原 See all CD56 (NCAM1) 抗体
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD56 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- 特异性
- Human and mouse.
- 纯化方法
- Purified
- 免疫原
- RNL-1 is a mouse monoclonal IgG1 antibody derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with the small cell lung cancer cell line NCI-H82.
- 克隆位点
- RNL-1
- 亚型
- IgG1
- Top Product
- Discover our top product NCAM1 Primary Antibody
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anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 759-858) antibody
NCAM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibodyNCAM1 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 5B1G11 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibodyNCAM1 适用: 人, 大鼠 FACS, WB, IHC, IF, StM 宿主: 小鼠 Monoclonal NCAM1-795 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (Internal Region) antibodyVerified NCAM1 适用: 人 FACS, WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibody (PerCP)NCAM1 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-188 PerCP
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 568-708) antibodyNCAM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F6F10 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 701-800) antibodyNCAM1 适用: 人, 大鼠, 小鸡 FACS, WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 340-608) antibodyNCAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 796-830), (C-Term) antibodyNCAM1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB51135 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 829-863), (C-Term) antibodyNCAM1 适用: 人 FACS, WB 宿主: 兔 Polyclonal RB51136 unconjugated
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- 应用备注
- RNL-1 was defined as a cluster I antibody during the Second International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. RNL-1 recognizes NCAM which is present in small cell lung cancer (SCLC) and lung carcinoids. RNL-1 is suitable for immunocytochemistry and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent.
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Lasting changes induced by mild alcohol exposure during embryonic development in BDNF, NCAM and synaptophysin-positive neurons quantified in adult zebrafish." in: The European journal of neuroscience, Vol. 47, Issue 12, pp. 1457-1473, (2018) (PubMed).
: "Neuronal differentiation is accompanied by NSP-C expression." in: Cell and tissue research, Vol. 292, Issue 2, pp. 229-37, (1998) (PubMed).
: "Immunoscintigraphy of small-cell lung cancer xenografts with anti neural cell adhesion molecule monoclonal antibody, 123C3: improvement of tumour uptake by internalisation." in: British journal of cancer, Vol. 73, Issue 4, pp. 439-46, (1996) (PubMed).
: "Hot spots of antigenicity in the neural cell adhesion molecule NCAM." in: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 8, pp. 38-42, (1994) (PubMed).
: "Novel antigens characteristic of neuroendocrine malignancies." in: Cancer, Vol. 67, Issue 3, pp. 619-33, (1991) (PubMed).
: "Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts." in: International journal of cancer. Journal international du cancer, Vol. 48, Issue 3, pp. 457-62, (1991) (PubMed).
: "Immunotargeting of human small cell lung cancer xenografts in athymic mice using a monoclonal antibody (RNL-1) against a neuroendocrine-related antigen." in: The British journal of cancer. Supplement, Vol. 14, pp. 78-81, (1991) (PubMed).
: "Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212." in: Cancer research, Vol. 50, Issue 4, pp. 1102-6, (1990) (PubMed).
: "Characterization and properties of nine human ovarian adenocarcinoma cell lines." in: Cancer research, Vol. 48, Issue 21, pp. 6166-72, (1988) (PubMed).
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: "Lasting changes induced by mild alcohol exposure during embryonic development in BDNF, NCAM and synaptophysin-positive neurons quantified in adult zebrafish." in: The European journal of neuroscience, Vol. 47, Issue 12, pp. 1457-1473, (2018) (PubMed).
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- 抗原
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
- 别名
- NCAM / CD56 (NCAM1 产品)
- 背景
- NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
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