cesd antibody, lal antibody, LIPA antibody, CESD antibody, LAL antibody, Chole antibody, Chole2 antibody, Lip1 antibody, AA960673 antibody, Lal antibody, Lip-1 antibody, lipase A, lysosomal acid type antibody, lipase A, lysosomal acid, cholesterol esterase antibody, lipase A, lysosomal acid, cholesterol esterase L homeolog antibody, lysosomal acid lipase A antibody, LIPA antibody, lipa antibody, lipa.L antibody, Lipa antibody
背景
LAL functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries. Synonyms: Monoclonal LAL antibody, Anti-LAL antibody, Lysosomal acid lipase antibody.