ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
NHE7 antibody, wu:fk03b09 antibody, zgc:101088 antibody, zgc:113878 antibody, A530087D17Rik antibody, NHE-7 antibody, SLC9A6 antibody, Nhe7 antibody, solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 antibody, solute carrier family 9 (sodium/hydrogen exchanger), member 7 antibody, solute carrier family 9 member A7 antibody, slc9a7 antibody, Slc9a7 antibody, SLC9A7 antibody
背景
Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of N+ and H+ ions in various tissues. The NHE catalyzes the electroneural transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH ( pH i) in addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. At least 7 NHE isoforms (NHE1-7) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The C-terminal domain of NHEs are predicted to be intracellular. NHE7 (human 725 aa, chromosome Xp11.4) is ubiquitously expressed, and predominantly localizes to the trans-golgi network. NHE7 mediates the influx of Na+ or K+ in exchange for H+. It is ~70 % related to NHE6 but relatively less (~25 %) homologous with other NHEs.Synonyms: NHE-7, Na(+)/H(+) exchanger 7, Sodium/hydrogen exchanger 7, Solute carrier family 9 member 7