ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
GPR106 antibody, GREAT antibody, INSL3R antibody, LGR8 antibody, LGR8.1 antibody, RXFPR2 antibody, Gpcr antibody, Lgr8 antibody, Gpr106 antibody, Great antibody, lgr8.1 antibody, rxfp2 antibody, rxfp2b antibody, zgc:63668 antibody, relaxin/insulin like family peptide receptor 2 antibody, relaxin/insulin-like family peptide receptor 2 antibody, relaxin/insulin-like family peptide receptor 2a antibody, RXFP2 antibody, Rxfp2 antibody, rxfp2a antibody
背景
Relaxins are endocrine and autocrine/paracrine hormones belonging to the insulin gene superfamily. In several mammalian species, relaxin is best known for its role during pregnancy and parturition, when it is produced by the corpora lutea of ovaries and other reproductive tissues. The secretion of relaxin into the blood stream just before parturition results in a marked softening and lengthening of the pubic symphysis and a softening of the cervix, which facilitates the birth process. Also, by inhibiting uterine contractions, relaxin may influence the timing of parturition. Two previously characterized orphan receptors designated relaxin receptor 1 (LGR7) and 2 (LGR8) bind relaxin in several tissues, including reproductive tissues, brain, and heart. Upon ligand binding, the relaxin receptors activate adenylate cyclases through Gs proteins. Expression of the relaxin receptors in tissues other than reproductive ones suggests that they have additional physiological functions, such as regulating blood pressure and controlling vascular volume in the heart.Synonyms: G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, GPR106, GREAT, LGR8, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2