Yeast Tup 1p-Ssn6p repressor complex represents a novel paradigm for transcriptional repression and for the role of chromatin in repression. TUP 1 and SSN6 are involved in repression of several diverse families of genes in yeast, including cell type-specific genes regulated by the alphga2 and a1/alpha2 repressors. Ssn6-Tupl interacts with class I histone deacetylases required for repression, and rfecrfuitment of yeast Tuplp-Ssn6p repressor is associated with localized decreases in histone acetylation. Synonyms: General transcriptional corepressor TUP1, Glucose repression regulatory protein TUP1, Flocculation suppressor protein, Repressor AER2, TUP1, AAR1, AER2, AMM1, CYC9, FLK1, SFL2, UMR7, YCR084C, YCR84.