BAX 抗体
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- 抗原 See all BAX 抗体
- BAX (BCL2-Associated X Protein (BAX))
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适用
- 小鼠
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宿主
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绵羊
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克隆类型
- 多克隆
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标记
- This BAX antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 交叉反应
- 小鼠
- 产品特性
- Apoptosis regulator Bax cytoplasmic isoform beta , BaxB, BAX, BCL2 associated X protein, Apoptosis regulator BAX, BCL2 associated X protein isoform beta, Bax beta, Bax B,Bax is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax protein before a stop codon is encountered during translation. The Bax protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax mRNA was very abundant in brain and duodenum with almost no Bax mRNA detected in these tissues (Oltvai et al., 1993).
- 纯化方法
- Ammonium Sulfate Precipitation
- 免疫原
- Synthetic peptide corresponding to amino acids 172 to 199 of theBax protein
- 亚型
- IgG
- Top Product
- Discover our top product BAX Primary Antibody
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- 应用备注
- Antibody detects Bax? protein by immunoprecipitation only. Will not detect denatured protein by Western blot. Optimal concentration should be evaluated by serial dilutions.
- 限制
- 仅限研究用
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- 缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- 抗原
- BAX (BCL2-Associated X Protein (BAX))
- 别名
- Bax-beta (BAX 产品)
- UniProt
- Q07812
- 途径
- p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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