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- 抗原
- Farnesyl
-
宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
- 应用范围
- Immunofluorescence (IF), ELISA
- 产品特性
- Protein isoprenylation is a post-translational modification that affects about 0.5 % of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze the attachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which are prenylated by these enzymes have a distinct motif at the C-terminal of the protein, C-A1-A2-X (C = Cysteine, A1 & A2 = aliphatic amino acids). The two enzymes involved in this transfer are farnesyltransferase and geranylgeranyltransferase. These transfer a 15 carbon farnesyl or a 20 carbon geranygeranyl, respectively, from a prenyl-pyrophosphate to the protein. Examples of proteins containing this C-A-A-X motif are members of the Ras small G protein family, the nuclear lamins and the gamma subunit of trimeric G proteins. Prenylation of proteins is necessary for membrane association of proteins as well as protein-protein interactions and the nature of the linked isoprenyl group can influence the protein interactions, such as the interaction between G proteins and receptors.
- 纯化方法
- Ammonium Sulfate Precipitation
- 免疫原
- Rabbit immunized with farnesyl cysteine conjugated to KLH.
- 亚型
- IgG
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anti-Farnesyl antibody
IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal concentration should be evaluated by serial dilutions.
- 限制
- 仅限研究用
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- 缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- 抗原
- Farnesyl
- 物质类
- Chemical
- UniProt
- P14324
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