PPP4R1 抗体 (AA 1-205)
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- 抗原 See all PPP4R1 抗体
- PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))
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抗原表位
- AA 1-205
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PPP4R1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应 （详细）
- Human, mouse, rat
- 产品特性
- Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1, Protein Phosphatase X/A'2, PP4R1,Clone 4A4 binds to all known Isotypes of p63. It is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei). It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80 % of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma. The p63 gene is a homologue of the tumour suppressor gene p53. It is highly expressed in nuclei of basal cells, the progenitor cells of many epithelial tissues. It shows up remarkable structural similarities to p53. By alternative splicing at least 6 different isoforms are synthesised, which are different in the C-terminus (alpha, beta, gamma) and in the N-terminus (TA and DN). In mice loss of the p63 gene leads to inability to form basal cells and severe organic deficits. Similar organic failures occur in humans with autosomal dominant EEC-Syndrome, which obviously is related to mutation of the p63 gene. p63 (6 Isotypes).
- 免疫原
- Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63
- 亚型
- IgG
- Top Product
- Discover our top product PPP4R1 Primary Antibody
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anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 324-647) antibody
PPP4R1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) antibodyPPP4R1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (N-Term) antibodyPPP4R1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 114-348) antibodyPPP4R1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Pre-treatment of formaldehyde-fixed tissue with Tris-buffered EDTA solution pH 9 or Unmasking Fluid G 40 min at 100 °C,IHC(P),60 min at RT,(liquid conc.) 1:25-1:50
- 限制
- 仅限研究用
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- 缓冲液
- Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for 250-500 immunohistochemical tests (100 μL working solution / test). Use appropriate antibody diluent
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- 2-8°C
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- 抗原
- PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))
- 别名
- Protein Phosphatase 4 R1 (X/A'2) (PPP4R1 产品)
- 别名
- MGC55603 antibody, zgc:55603 antibody, ppp4r1 antibody, MGC81597 antibody, MGC89421 antibody, PPP4R1 antibody, MEG1 antibody, PP4(Rmeg) antibody, PP4R1 antibody, 3110001J10Rik antibody, Pp4r1 antibody, protein phosphatase 4 regulatory subunit 1 antibody, protein phosphatase 4, regulatory subunit 1 antibody, protein phosphatase 4 regulatory subunit 1 S homeolog antibody, PPP4R1 antibody, ppp4r1 antibody, ppp4r1.S antibody, Ppp4r1 antibody
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