CD45RB 抗体
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- 抗原 See all CD45RB 抗体
- CD45RB
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD45RB antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF)
- 产品特性
- Monoclonal Anti-Mouse CD45RB is recommended for use in flow cytometry for identification of CD45RB, an isoform of CD45. The C363-16A react with an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1. The anti-mouse CD45RB monoclonal antibody reacts with the CD45 isoform containing the exon B dependent epitope. CD45RB is highly expressed on peripheral B cells, cytotoxic T cells, a subset of T helper cells and most thymoctyes.
- 免疫原
- Cloned mouse Th2 cell lines.
- 克隆位点
- C363-16A
- 亚型
- IgG2a
- Top Product
- Discover our top product CD45RB Primary Antibody
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anti-CD45RB (CD45RB) antibody
CD45RB 适用: 人, Non-Human Primate FACS, WB, IHC (p), IP 宿主: 小鼠 Monoclonal MEM-55 unconjugated
anti-CD45RB (CD45RB) antibody (FITC)CD45RB 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-55 FITC
anti-CD45RB (CD45RB) antibody (PE)CD45RB 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-55 PE
anti-CD45RB (CD45RB) antibody (APC)CD45RB 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-55 APC
anti-CD45RB (CD45RB) antibody (PE)CD45RB 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal C363-16A PE
anti-CD45RB (CD45RB) (AA 79-88) antibodyCD45RB 适用: 人 FACS, IHC, IHC (p) 宿主: 小鼠 Monoclonal MEM-143 unconjugated
anti-CD45RB (CD45RB) antibodyCD45RB 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal C363-16A unconjugated
anti-CD45RB (CD45RB) antibodyCD45RB 适用: 人, 猴, 猕猴, 兔 FACS, IHC, IHC (p), IP, IHC (fro) 宿主: 小鼠 Monoclonal MEM55 unconjugated
anti-CD45RB (CD45RB) antibody (APC)CD45RB 适用: 人, 猴, 猕猴 FACS, IHC, IHC (p), IP, IHC (fro) 宿主: 小鼠 Monoclonal MEM-55 APC
anti-CD45RB (CD45RB) antibody (FITC)CD45RB 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal C363-16A FITC
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- 应用备注
- It is recommended for use in flow cytometry. This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is less or equal to 1 µg per 10^6 cells in 100 µL volume.
- 说明
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Purified, unconjugated.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- The conjugate is provided in liquid form in buffer containing PBS, 1% BSA and 0.09 % Sodium azide, pH 7,4.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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- 抗原
- CD45RB
- 别名
- CD45RB (CD45RB 产品)
- 别名
- B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, PTPRC antibody, Ptprc antibody
- 背景
- CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions.
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