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CD68 抗体 (Middle Region)

CD68 适用: 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Anti-CD68 antibody, IHC(P) IHC(P): Mouse Liver Tissue (CD68 抗体 (Middle Region))

Western Blotting (WB) image for anti-CD68 Molecule (CD68) (AA 312-326), (Middle Region) antibody (ABIN3044428) (CD68 抗体 (Middle Region))

Anti-CD68 antibody, Western blotting Lane 1: Rat Spleen Tissue Lysate Lane 2: Mouse Spleen Tissue Lysate Lane 3: Mouse RAW246. (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(F) IHC(F): Rat Liver Tissue (CD68 抗体 (Middle Region))

Anti-CD68 antibody, Western blotting Lane 1: Rat Spleen Tissue Lysate Lane 2: Rat Lung Tissue Lysate (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(P) IHC(P): Mouse Spleen Tissue (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(P) IHC(P): Rat Liver Tissue (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(P) IHC(P): Mouse Spleen Tissue (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(P) IHC(P): Rat Spleen Tissue (CD68 抗体 (Middle Region))

Anti-CD68 antibody, IHC(P): Rat Liver Tissue (CD68 抗体 (Middle Region))

10 images

(34 references)

产品编号 ABIN3044428

发货至: 中国

Datasheet as PDF

抗原 See all CD68 抗体

CD68 (CD68 Molecule (CD68))
抗原表位
15

8

6

5

5

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 312-326, Middle Region
适用
140

55

39

29

26

14

9

2

2

2

2
小鼠, 大鼠
宿主
86

68

11

1
兔
Compatible Secondaries
克隆类型
102

60
多克隆
标记
78

13

12

9

3

3

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD68 antibody is un-conjugated
应用范围
75

71

49

36

35

34

26

21

10

10

8

4

3

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

原理

Rabbit IgG polyclonal antibody for Macrosialin(CD68) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.

序列

AFCITRRRQS TYQPL

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Macrosialin(CD68) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.
Gene Name: CD68 Molecule
Protein Name: Macrosialin

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence in the middle region of mouse CD68(312-326aa AFCITRRRQSTYQPL), different from the related rat sequence by one amino acid.

亚型

IgG
anti-CD68 Molecule (CD68) (AA 42-155) antibody
CD68 适用: 人 FACS, WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3F7D3 unconjugated

anti-CD68 Molecule (CD68) (AA 21-120) antibody
CD68 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), ICC, IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人, 小鼠, 大鼠, 猴 FACS, WB, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal C68-684 unconjugated

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-CD68 Molecule (CD68) (AA 150-301) antibody
CD68 适用: 人 FACS, IHC, ISt, ELISA, StM, Coat 宿主: 小鼠 Monoclonal LAMP4-1830 unconjugated

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人 FACS, WB, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal rLAMP4-824 unconjugated Recombinant Antibody

anti-CD68 Molecule (CD68) antibody
CD68 适用: 人, 小鼠, 大鼠 IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated

anti-CD68 Molecule (CD68) (AA 150-221) antibody
CD68 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal C68-2709 unconjugated

anti-CD68 Molecule (CD68) antibody (PE)
CD68 适用: 人 FACS 宿主: 小鼠 Monoclonal Y1-82A PE

anti-CD68 Molecule (CD68) (AA 22-319) antibody
CD68 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Spronck, Ramachandra, Moriyama, Toczek, Han, Sadeghi, Humphrey: "Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice." in: Journal of biomechanics, Vol. 141, pp. 111179, (2022) (PubMed).

Liu, Huang, Su, Song, Lu: "Blockage of Galectin-receptor Interactions by α-lactose Exacerbates Plasmodium berghei-induced Pulmonary Immunopathology." in: Scientific reports, Vol. 6, pp. 32024, (2018) (PubMed).

Yin, Chang, Xu: "Expressions Profiles of the Proteins Associated with Carbohydrate Metabolism in Rat Liver Regeneration." in: BioMed research international, Vol. 2017, pp. 8428926, (2018) (PubMed).

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Pang, Zhang, Huang, Xu, Wang, Wang, Guan, Zhang, Yu, Chen, Xie: "Effects and Mechanisms of Total Flavonoids from Blumea balsamifera (L.) DC. on Skin Wound in Rats." in: International journal of molecular sciences, Vol. 18, Issue 12, (2018) (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." in: EBioMedicine, Vol. 28, pp. 17-18, (2018) (PubMed).

Lin, Li, Cai, Huang, Huang, Guo, Yang, Yang, Lan, Zhu: "Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways." in: Oxidative medicine and cellular longevity, Vol. 2018, pp. 7808656, (2018) (PubMed).

Guo, Liao, Huang, Wang, Huang, Liu: "Reversal of adipose tissue loss by probucol in mice with deficiency of both scavenger receptor class B type 1 and LDL receptor on high fat diet." in: Biochemical and biophysical research communications, (2017) (PubMed).

Wang, Liu, Xiong, Xu, Shi, Qiu, Zang, Mao, Zhuang: "Inhibition of EGF Receptor Blocks the Development and Progression of Peritoneal Fibrosis." in: Journal of the American Society of Nephrology : JASN, Vol. 27, Issue 9, pp. 2631-44, (2017) (PubMed).

Liu, Xiao, Liu, Li, Zhou, Xian, Wang, Zhang, Wang, Ho, Zhuang: "SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 11, Issue 3, pp. 592-600, (2017) (PubMed).

Yang, Zhang, Yu, Tang, Gan: "Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation." in: International journal of molecular medicine, Vol. 39, Issue 3, pp. 613-621, (2017) (PubMed).

Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

Leftin, Ben-Chetrit, Klemm, Joyce, Koutcher: "Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer." in: PLoS ONE, Vol. 12, Issue 9, pp. e0184765, (2017) (PubMed).

Leftin, Zhao, Turkekul, de Stanchina, Manova, Koutcher: "Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer." in: Scientific reports, Vol. 7, Issue 1, pp. 11632, (2017) (PubMed).

Huang, Zhang, Guo, Huang, Yang, Chen, Huang, Zhang, Long, Yang: "Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts." in: Scientific reports, Vol. 7, Issue 1, pp. 11989, (2017) (PubMed).

Wang, Tian, Chen, Tan, Xie, Chen, Fu, Chen, Xu, Wei: "Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice." in: Scientific reports, Vol. 7, Issue 1, pp. 14707, (2017) (PubMed).

Qu, Bing, Meng, Xi, Bai, Liu, Guo, Zhao, Bi: "Upregulation of miR-126-3p promotes human saphenous vein endothelial cell proliferation in vitro and prevents vein graft neointimal formation ex vivo and in vivo." in: Oncotarget, Vol. 8, Issue 63, pp. 106790-106806, (2017) (PubMed).

Wang, Zhang, Chai, Liu, Li, Wang, Zhu, Cui, Qu, Zhu: "1,25(OH)2D3 downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats." in: Journal of endocrinological investigation, Vol. 38, Issue 10, pp. 1083-91, (2016) (PubMed).

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show more references
抗原

CD68 (CD68 Molecule (CD68))

别名

CD68 (CD68 产品)

别名

Lamp4 antibody, Scard1 antibody, gp110 antibody, GP110 antibody, LAMP4 antibody, SCARD1 antibody, CD68 molecule antibody, CD68 antigen antibody, Cd68 molecule antibody, CD68 antibody, Cd68 antibody

背景

CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia(the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.

Synonyms: CD 68 antibody|CD68 antibody|CD68 antigen antibody|CD68 Molecule antibody|CD68_HUMAN antibody|DKFZp686M18236 antibody|GP110 antibody|LAMP4 antibody|Macrophage antigen CD68(microsialin) antibody|MACROPHAGE ANTIGEN CD68 antibody|macrosialin antibody|SCARD1 antibody|Scavenger receptor class D member 1 antibody

UniProt

P31996

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