GDNF 抗体 (Middle Region)
(4 references)-
- 抗原 See all GDNF 抗体
- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
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抗原表位
- AA 142-158, Middle Region
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GDNF antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Glial cell line-derived neurotrophic factor(GDNF) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
- 序列
- FRYCSGSCDA AETTYDK
- 交叉反应 （详细）
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Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - 产品特性
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Rabbit IgG polyclonal antibody for Glial cell line-derived neurotrophic factor(GDNF) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: glial cell derived neurotrophic factor
Protein Name: Glial cell line-derived neurotrophic factor(hGDNF) - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human GDNF(142-158aa FRYCSGSCDAAETTYDK), different from the related mouse sequence by three amino acids and rat sequence by two amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product GDNF Primary Antibody
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anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 121-211) antibody
GDNF 适用: 人, 小鼠, 大鼠, Cow, 兔 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibodyGDNF 适用: 人 WB, IHC, ELISA, IP, FACS 宿主: 兔 Monoclonal 11D2 unconjugated Recombinant Antibody
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 8-36) antibodyGDNF 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibody (HRP)GDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal HRP
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibody (Atto 594)GDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 594
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibody (Atto 488)GDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 488
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibody (Atto 390)GDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 390
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 109-211) antibodyGDNF 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibodyGDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glial Cell Line Derived Neurotrophic Factor (GDNF) antibody (FITC)GDNF 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal FITC
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - 有效期
- 12 months
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: "Surface functionalization of TiO2 nanotubes with minocycline and its in vitro biological effects on Schwann cells." in: Biomedical engineering online, Vol. 17, Issue 1, pp. 88, (2018) (PubMed).
: "Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells." in: Reproductive toxicology (Elmsford, N.Y.), Vol. 45, pp. 87-93, (2014) (PubMed).
: "Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction." in: Neural regeneration research, Vol. 8, Issue 23, pp. 2190-7, (2014) (PubMed).
: "S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk." in: PLoS ONE, Vol. 6, Issue 6, pp. e21663, (2011) (PubMed).
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: "Surface functionalization of TiO2 nanotubes with minocycline and its in vitro biological effects on Schwann cells." in: Biomedical engineering online, Vol. 17, Issue 1, pp. 88, (2018) (PubMed).
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- 抗原
- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
- 别名
- GDNF (GDNF 产品)
- 别名
- gdnf antibody, GDNF antibody, AI385739 antibody, gdnfa antibody, hfb1-gdnf antibody, ATF1 antibody, ATF2 antibody, HFB1-GDNF antibody, HSCR3 antibody, glial cell derived neurotrophic factor antibody, glial cell derived neurotrophic factor a antibody, glial cell line derived neurotrophic factor antibody, glial cell derived neurotrophic factor L homeolog antibody, Gdnf antibody, gdnfa antibody, GDNF antibody, gdnf.L antibody
- 背景
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GDNF, Glial cell-derived neurotrophic factor, is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF is a founding member of the GDNF family of ligands(GFL). The GDNF gene is mapped to human chromosome 5p13.1-p12 by fluorescence in situ hybridization(FISH). This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosisof motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET(rearranged during transfection) protooncogene.
Synonyms: gdnf antibody|GDNF_HUMAN antibody|Glial cell derived neurotrophic factor antibody|Glial Cell Line Derived Neurotrophic Factor antibody|Glial cell line-derived neurotrophic factor antibody|Glial derived neurotrophic factor antibody|HFB1 GDNF antibody|hGDNF antibody|HSCR3 antibody - UniProt
- P39905
- 途径
- RTK signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
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