MMP8 抗体 (N-Term)
(4 references)-
- 抗原 See all MMP8 抗体
- MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))
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抗原表位
- AA 119-153, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MMP8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Neutrophil collagenase(MMP8) detection. Tested with WB, IHC-P, ELISA in Human.
- 序列
- NYTPQLSEAE VERAIKDAFE LWSVASPLIF TRISQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Neutrophil collagenase(MMP8) detection. Tested with WB, IHC-P, ELISA in Human.
Gene Name: matrix metallopeptidase 8 (neutrophil collagenase)
Protein Name: Neutrophil collagenase - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human MMP-8 (119-153aa NYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQ), different from the related mouse sequence by eleven amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MMP8 Primary Antibody
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anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 101-467) antibody
MMP8 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C8 unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) antibodyMMP8 适用: 人 WB, IHC (p), IP, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) antibodyMMP8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 120-157), (N-Term) antibodyMMP8 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 241-340) antibodyMMP8 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 22-283) antibodyMMP8 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) antibodyMMP8 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 1-467) antibodyMMP8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 1-467) antibodyMMP8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (C-Term) antibodyMMP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).
: "Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats." in: Frontiers in pharmacology, Vol. 6, pp. 215, (2015) (PubMed).
: "Expression of matrix metalloproteinases-8 and -9 and their tissue inhibitor in the condyles of diabetic rats with mandibular advancement." in: Experimental and therapeutic medicine, Vol. 8, Issue 5, pp. 1357-1364, (2014) (PubMed).
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: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
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- 抗原
- MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))
- 别名
- MMP8 (MMP8 产品)
- 别名
- MMP8 antibody, BB138268 antibody, CLG1 antibody, HNC antibody, MMP-8 antibody, PMNL-CL antibody, matrix metallopeptidase 8 antibody, neutrophil collagenase antibody, MMP8 antibody, Mmp8 antibody, LOC100339790 antibody
- 背景
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MMP8 (Matrix metalloproteinase 8) is a member of the family of matrix metalloproteinases. It is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8 is mapped to 11q21-q22. MMP8 is an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The enzyme exhibits 58 % homology to human fibroblast collagenase and has the same domain structure. It consists of a 20-residue signal peptide, and an 80-residue propeptide that is lost on autolytic activation by cleavage of an M-L bond. MMP8 was found to possess 57 % identity with the deduced protein sequence for fibroblast collagenase with 72 % chemical similarity. Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer. MMP8 has a paradoxical protective role in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility.
Synonyms: CLG 1 antibody|CLG1 antibody|Collagenase 1 antibody|Collagenase 1 neutrophil antibody|HNC antibody|Matrix metallopeptidase 8 (neutrophil collagenase) antibody|Matrix metalloprotease 8 antibody|Matrix metalloproteinase-8 antibody|MMP 8 antibody|MMP-8 antibody| Mmp8 antibody| MMP8_HUMAN antibody|Neutrophil collagenase antibody|PMNL CL antibody|PMNL collagenase antibody|PMNL-CL antibody|PMNLCL antibody - 基因ID
- 4317
- UniProt
- P22894
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