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NFKBIB 抗体 (AA 56-237)

NFKBIB 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043567
发货至: 中国
  • 抗原 See all NFKBIB 抗体
    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
    抗原表位
    • 28
    • 15
    • 13
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 56-237
    适用
    • 113
    • 42
    • 35
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 104
    • 10
    克隆类型
    • 97
    • 17
    多克隆
    标记
    • 55
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This NFKBIB antibody is un-conjugated
    应用范围
    • 84
    • 41
    • 30
    • 28
    • 27
    • 18
    • 11
    • 7
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for NF-kappa-B inhibitor beta(NFKBIB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for NF-kappa-B inhibitor beta(NFKBIB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
    Protein Name: NF-kappa-B inhibitor beta
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human IKB beta recombinant protein (Position: E56-E237). Human IKB beta shares 82% and 80% amino acid (aa) sequence identity with mouse and rat IKB beta, respectively.
    亚型
    IgG
    Top Product
    Discover our top product NFKBIB Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for IKB beta is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • 抗原
    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
    别名
    NFKBIB (NFKBIB 产品)
    别名
    NFKBIB antibody, IKB-beta antibody, IKappaBbeta antibody, IkB antibody, IkBb antibody, IKBB antibody, TRIP9 antibody, NFKB inhibitor beta antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antibody, NFKBIB antibody, Nfkbib antibody
    背景
    NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. This gene is mapped to 19q13.2. It has been found that in vivo, NFKBIB serves both to inhibit and to facilitate the inflammatory response. NFKBIB degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as TNF-alpha. Surprisingly, absence of NFKBIB results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.

    Synonyms: I kappa B beta antibody|I-kappa-B-beta antibody|IkappaBbeta antibody|IKB beta antibody|IkB-B antibody|IkB-beta antibody|IKBB antibody|IKBB_HUMAN antibody|IkBbeta antibody|NF kappa BIB antibody|NF-kappa-B inhibitor beta antibody|NF-kappa-BIB antibody|Nfkbib antibody|Thyroid receptor interacting protein 9 antibody|Thyroid receptor-interacting protein 9 antibody|TR interacting protein 9 antibody|TR-interacting protein 9 antibody|TRIP-9 antibody|TRIP9 antibody
    基因ID
    4793
    UniProt
    Q15653
    途径
    NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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